Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Vacuolar H+-ATPase d2 subunit: molecular characterization, developmental regulation, and localization to specialized proton pumps in kidney and bone.
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ATP6V0D2 shows tissue-restricted expression in kidney and bone
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d2 localizes to apical plasma membrane of intercalated cells in kidney collecting duct
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d2 co-localizes with a4 subunit in kidney and a3 subunit in osteoclasts
The d subunit plays a central role in human vacuolar H(+)-ATPases.
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d2 directly interacts with V1 subunits D and F
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d2 is structurally similar to bacterial A-ATPase subunit C
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d2 forms part of the pump's central stalk and is important in rotary mechanism
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.
A reference map of the human binary protein interactome.
Intraphagosomal pH is lowered to 5 by V-ATPase
Acidification of Tf:TfR1 containing endosome
RRAGC,D exchanges GTP for GDP
RRAGA,B exchanges GDP for GTP
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine
v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2alpha.
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ATP6V0D2 promotes autophagosome-lysosome fusion through RAB7/HOPS and SNARE-complex assembly in ccRCC models.
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ATP6V0D2 increases lysosomal acidification and activity during late autophagy in ccRCC models.
Falcon deep research report for ATP6V0D2
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ATP6V0D2 is a V-ATPase V0 d2 subunit with evidence for specialized kidney, osteoclast, lysosomal, and late-autophagy roles.
ATP6V0D2 PN curation notes
Proteostasis Network autophagy-lysosome pathway mappings