MAP7D3 (MAP7 Domain-Containing Protein 3) – Function and Significance OpenAI o3-deep-research-2025-06-26 113 citations 2025-12-27T20:43:12.111196

MAP7D3 (MAP7 Domain-Containing Protein 3) – Function and Significance

Gene Identity and Structure

MAP7D3 (also known as Mdp3) is a human gene on the X chromosome encoding a 876-amino-acid protein that belongs to the microtubule-associated protein 7 (MAP7) family (www.genecards.org) (www.genecards.org). Like other MAP7 family members, MAP7D3 contains two conserved helical coiled-coil domains (at the N-terminus and near the C-terminus) separated by an unstructured linker (pmc.ncbi.nlm.nih.gov). The N-terminal region of MAP7D3 is a strong microtubule-binding domain, while the C-terminal region includes the so-called MAP7 domain (pmc.ncbi.nlm.nih.gov). This C-terminal MAP7 domain is known to interact with the stalk of kinesin motor proteins in the MAP7 family, as shown for MAP7 (ensconsin) (pmc.ncbi.nlm.nih.gov). Notably, MAP7D3 features an additional microtubule-interacting segment in its extreme C-terminus, meaning it can bind microtubules through both its N-terminal coiled-coils and its C-terminal tail (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). This multi-domain architecture suggests MAP7D3 can serve as a scaffold on microtubules, engaging both the tubulin polymer and motor or regulatory proteins.

Microtubule Binding and Stabilization

MAP7D3’s primary function is to promote microtubule assembly and stability. Initial studies identified Mdp3 (MAP7D3) as a novel microtubule-binding protein that protects microtubules from depolymerizing stresses (journals.plos.org). In vitro assays demonstrated that MAP7D3 can enhance tubulin polymerization and stabilize microtubules against disassembly (pmc.ncbi.nlm.nih.gov). The N-terminal domain (coiled-coils) of MAP7D3 mediates direct binding to tubulin polymers, while the C-terminal MAP7 domain and tail also contribute to binding the microtubule lattice – even overlapping with classic MAP binding sites such as that of tau protein (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). By binding along microtubule filaments, MAP7D3 acts as a structural MAP (microtubule-associated protein) that supports the polymer’s integrity. Consistently, depletion of MAP7D3 destabilizes microtubules: cells with MAP7D3 knocked down show increased microtubule disassembly in cold or drug-induced depolymerization experiments (journals.plos.org) (journals.plos.org). Conversely, overexpression of MAP7D3 helps maintain a higher fraction of tubulin in the polymerized state under stress conditions (journals.plos.org).

One mechanism by which MAP7D3 stabilizes microtubules is through regulation of tubulin acetylation. MAP7D3 physically interacts with histone deacetylase 6 (HDAC6) – a cytoplasmic deacetylase that targets α-tubulin. The N-terminus of MAP7D3 binds to HDAC6 in addition to tubulin (journals.plos.org) (journals.plos.org). This interaction sequesters or inhibits HDAC6, thereby preserving the acetylation of microtubules. Acetylated microtubules are generally more stable, and indeed knockdown of MAP7D3 leads to a significant reduction in acetylated α-tubulin levels in cells (pubmed.ncbi.nlm.nih.gov) (pubmed.ncbi.nlm.nih.gov). MAP7D3 and HDAC6 colocalize in the cytoplasm, and loss of MAP7D3 increases HDAC6’s tubulin-deacetylase activity (journals.plos.org). Thus, MAP7D3 promotes microtubule stability both by direct binding and by restraining HDAC6, which keeps microtubules in a more acetylated (stable) state (journals.plos.org) (journals.plos.org). This dual action underscores MAP7D3’s role as a microtubule stabilizer in the cell.

Role in Cell Division and Spindle Dynamics

MAP7D3 is strongly implicated in the organization of the mitotic spindle – the microtubule apparatus that segregates chromosomes during cell division. During mitosis, MAP7D3 localizes to spindle microtubules and the centrosomes, where it helps maintain spindle stability. A 2016 study (Kwon et al. 2016) showed that MAP7D3 (Mdp3) forms a complex with DDA3 (also known as PSRC1) at the spindle and regulates microtubule dynamics at the spindle poles (the microtubule minus-ends) (pubmed.ncbi.nlm.nih.gov). Specifically, MAP7D3 counteracts the activity of the kinesin-13 family depolymerase Kif2a at spindle minus-ends. DDA3 normally recruits Kif2a to spindle poles to promote microtubule depolymerization; MAP7D3 inhibits this recruitment, thus acting as a microtubule stabilizer at the spindle pole (pubmed.ncbi.nlm.nih.gov). In MAP7D3-depleted cells, excessive Kif2a activity at centrosomal microtubule minus-ends leads to unstable spindles and defects in chromosome alignment and segregation (pubmed.ncbi.nlm.nih.gov). Cells lacking MAP7D3 exhibit hallmark mitotic errors such as misaligned metaphase chromosomes, lagging chromosomes in anaphase, and an increase in chromatin bridges during telophase/cytokinesis (pubmed.ncbi.nlm.nih.gov). This phenotype indicates that MAP7D3 is required for proper spindle microtubule attachment and force balance, preventing premature microtubule depolymerization at centrosomes. Importantly, MAP7D3 and DDA3 have opposing activities (stabilizing vs. destabilizing microtubules, respectively) but do not disturb each other’s localization on the spindle (pubmed.ncbi.nlm.nih.gov). Together, they form part of a regulatory complex that fine-tunes spindle microtubule turnover (poleward flux) to ensure accurate chromosome segregation (pubmed.ncbi.nlm.nih.gov).

Consistent with its spindle role, MAP7D3 has been observed at centrosomes, the microtubule-organizing centers. In breast cancer cells, γ-tubulin (a core component of centrosomes that nucleates microtubules) was found to bind MAP7D3 and recruit it to the centrosome (www.thno.org). This interaction is not merely structural; it has functional consequences for cell proliferation. MAP7D3’s localization to the centrosome is critical for its activity in cell growth – mutation or depletion that prevents Mdp3 from concentrating at centrosomes abrogates its ability to enhance cell proliferation and migration (www.thno.org). Thus, at the centrosome MAP7D3 may stabilize newly nucleated microtubule minus-ends or organize microtubule arrays needed for cell cycle progression. Overall, through centrosomal targeting and spindle-association, MAP7D3 ensures robust spindle microtubule assembly, contributing to genomic stability during division.

Interaction with Motor Proteins (Kinesin-1 Activation)

Beyond stabilizing microtubules, MAP7D3 serves as an adapter for motor protein attachment and cargo transport. Recent research has highlighted the MAP7 family as key positive regulators of kinesin-1, the major plus-end–directed motor that transports various cargoes along microtubules (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). All four mammalian MAP7 family members (MAP7, MAP7D1, MAP7D2, MAP7D3) can bind directly to kinesin-1 (pmc.ncbi.nlm.nih.gov). In particular, MAP7D3 was shown to bind the stalk region of kinesin-1 (KIF5B), which is the dimeric coiled-coil domain of the motor, through its C-terminal MAP7 domain (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Functionally, MAP7D3 (along with MAP7 and MAP7D1) is required to recruit and activate kinesin-1 in certain cellular contexts. For example, Hooikaas et al. (2019) demonstrated in HeLa cells that MAP7, MAP7D1, and MAP7D3 act redundantly to enable normal kinesin-driven mitochondrial transport – if all these MAP7 family members are removed, kinesin-1 cannot properly distribute mitochondria to the cell periphery (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Notably, knockout of MAP7D3 alone caused a partial defect in kinesin-driven cargo localization, indicating that MAP7D3 makes a unique contribution to motor transport even among the family (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov).

At the molecular level, MAP7D3 increases the ability of kinesin-1 to attach to microtubules and move processively. In vitro reconstitution assays with purified proteins show that adding MAP7D3 elevates the landing frequency of kinesin-1 on microtubules and extends the motor’s run length (distance traveled) (pmc.ncbi.nlm.nih.gov). Mechanistically, MAP7D3 works in two ways: (1) its N-terminal domain tethers kinesin along with itself to the microtubule (since the N-terminus binds microtubules tightly, it can serve as a “parking spot” for the motor), and (2) its C-terminal domain binds the kinesin stalk and may allosterically relieve kinesin’s autoinhibition (pmc.ncbi.nlm.nih.gov). The net effect is that MAP7D3 serves as a microtubule-bound co-factor that recruits kinesin-1 to microtubule tracks and activates its movement (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Indeed, MAP7 family proteins have been dubbed “microtubule-tethered kinesin-1 activators” (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov).

Interestingly, MAP7D3 displays different binding dynamics than MAP7 (ensconsin) when collaborating with kinesin. MAP7D3 has a higher affinity for kinesin-1 and a lower affinity for microtubules compared to MAP7 (pmc.ncbi.nlm.nih.gov). As a result, MAP7D3 can actually travel with the kinesin motor: it transiently hops on and off the microtubule, riding along as the motor progresses (pmc.ncbi.nlm.nih.gov). In contrast, MAP7 (the original family member) binds microtubules more stably and tends to stay fixed on the lattice, with the kinesin detaching from MAP7 as it walks. The ability of MAP7D3 to cotransport with kinesin-1 was observed as co-migration of MAP7D3 and a moving kinesin fragment in live-cell imaging (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). This suggests MAP7D3 may escort kinesin-1 and possibly its cargo to specific microtubule regions (such as plus-end–rich regions in the cell periphery) before detaching. In summary, MAP7D3 serves as a critical linker between microtubules and kinesin motors, enhancing cargo transport efficiency. This function has broad implications, because it means MAP7D3 can influence organelle localization, axonal transport in neurons (as shown for other MAP7s (pmc.ncbi.nlm.nih.gov)), and overall cell polarity and logistics.

Biological Processes and Localization

Given these molecular activities, MAP7D3 participates in several fundamental biological processes:
- Cytoskeleton organization: By stabilizing microtubules and interacting with centrosomes, MAP7D3 helps organize the microtubule network in interphase and during mitosis (pubmed.ncbi.nlm.nih.gov) (www.thno.org). This contributes to maintaining cell shape and an accurate cell division apparatus.
- Cell cycle progression: MAP7D3 levels oscillate with the cell cycle (high in G1/S/M, low in G2) (www.genecards.org), and its function at the spindle is crucial for proper chromosome segregation (pubmed.ncbi.nlm.nih.gov). Loss of MAP7D3 can cause mitotic delays or errors, potentially activating checkpoints due to misaligned chromosomes.
- Intracellular transport and cell polarity: Through kinesin-1 activation, MAP7D3 supports the distribution of organelles (e.g., mitochondria) and vesicles to the cell periphery (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). This influences cell polarity and the ability of cells to migrate or maintain asymmetric functions. In polarized cells like neurons, MAP7 family proteins (paralogs of MAP7D3) are known to assist axonal transport and branching (pmc.ncbi.nlm.nih.gov), so MAP7D3 may play analogous roles in cell types where it’s expressed.
- Cell adhesion and migration: Proper remodeling of microtubules is required for cell movement and adhesion dynamics. While most data on MAP7D3 in migration come from cancer cells (see below), other MAP7 proteins (MAP7 and MAP7D1) facilitate microtubule remodeling for cell motility in HeLa cells (pmc.ncbi.nlm.nih.gov). MAP7D3’s stabilization of microtubules and regulation of Rac1 GTPase activity (through cytoskeletal crosstalk) has been shown to affect lamellipodia formation and cell invasion behavior (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Furthermore, MAP7D3’s presence at focal microtubule-organizing centers (centrosomes) can impact how cells adhere and spread, since centrosomal microtubules target adhesion sites.

In terms of subcellular localization, MAP7D3 is an intracellular, cytoskeletal protein. It is predominantly found in the cytoplasm bound to microtubules. Immunostaining shows MAP7D3 decorating microtubule fibers throughout the cell (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov), consistent with it being a MAP. During mitosis it concentrates at mitotic spindles, especially near spindle poles (centrosome regions) (pubmed.ncbi.nlm.nih.gov). In interphase, a portion of MAP7D3 also localizes around the centrosome/centrioles due to its interaction with γ-tubulin (www.thno.org). Biochemical fractionation confirms that MAP7D3 is largely in the polymerized tubulin fraction (cytoskeletal fraction) rather than the soluble pool (pubmed.ncbi.nlm.nih.gov). MAP7D3 lacks any signal peptide or transmembrane domain, and it is not secreted; it functions within the cell where microtubules are present (v23.proteinatlas.org) (v23.proteinatlas.org).

Pathological and Clinical Significance

MAP7D3 has attracted interest in cancer biology, particularly as a promoter of tumor cell proliferation and metastasis. Its role in stabilizing microtubules links it to cancer progression: cancer cells often exploit cytoskeletal changes for increased migration and chemotherapy resistance. In breast cancer, MAP7D3 is notably upregulated. A research team in 2014 (Tala et al., Theranostics 2014) first reported that MAP7D3 is highly expressed in human breast tumors and correlates with more aggressive disease (www.thno.org) (www.thno.org). Patients’ tumor samples with higher MAP7D3 had indicators of malignancy such as higher grade and metastasis. Experimentally, silencing MAP7D3 in breast cancer cell lines reduced their proliferation and motility, while overexpression enhanced these traits (www.thno.org). In mouse models, MAP7D3 overexpression stimulated tumor growth and the spread of cancer cells to secondary sites, demonstrating a pro-metastatic function (www.thno.org). Mechanistic insight from this study showed that MAP7D3 is recruited to centrosomes by γ-tubulin in cancer cells, and this centrosomal targeting is required for its ability to drive cell division and migration (www.thno.org). By residing at the centrosome, MAP7D3 may help cancer cells maintain the robust microtubule arrays needed for rapid division and invasive movement. These findings established MAP7D3 as an oncogenic factor in breast cancer.

More recently, a 2023 study by Kuo et al. examined MAP7D3 in triple-negative breast cancer (TNBC) – a particularly aggressive subtype lacking hormone receptors. This comprehensive study identified MAP7D3 as a novel prognostic marker and potential therapeutic target in TNBC (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). MAP7D3 was the only MAP7-family member consistently overexpressed in highly metastatic TNBC cell sublines (versus their less metastatic parental cells) (pmc.ncbi.nlm.nih.gov). High MAP7D3 expression in patient datasets was significantly associated with TNBC cases (as opposed to other breast cancer subtypes) and with advanced clinical stage, positive lymph node (LN) metastasis, and poorer survival outcomes (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Remarkably, 63.8% of TNBC patients had higher MAP7D3 levels in metastatic lymph nodes than in their primary breast tumors, underlining its linkage with metastasis (pmc.ncbi.nlm.nih.gov). Functionally, silencing MAP7D3 in metastatic TNBC cells had profound effects: it suppressed cell migration, invasion, and anchorage-independent growth (all hallmarks of metastatic potential) (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Loss of MAP7D3 also re-sensitized TNBC cells to chemotherapy – knockdown cells became 2–3× more sensitive to the microtubule-targeting drug docetaxel and to gemcitabine, coinciding with lower expression of stemness/drug-resistance markers (ALDH1A1, ABCG2, Sox2, etc.) and reduced Rac1 GTPase activity (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). In vivo experiments reinforced these findings: shRNA-mediated MAP7D3 depletion dramatically slowed tumor growth and almost eliminated lung metastases in mouse xenograft models of TNBC (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Together, these results position MAP7D3 as a driver of an “aggressive phenotype” in TNBC, promoting both metastasis and chemoresistance (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Clinically, they suggest that high MAP7D3 expression could serve as a prognostic biomarker for poor outcome in TNBC, and that targeting MAP7D3 might impair tumor spread and improve chemotherapy response (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). The 2023 study concluded that inhibiting MAP7D3 is a promising therapeutic strategy to explore for combating TNBC progression and drug resistance (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov).

Beyond breast cancer, MAP7D3’s function may be relevant to other diseases involving cytoskeletal dysfunction. Because it is on the X chromosome, there has been interest in whether MAP7D3 mutations cause X-linked disorders. Notably, rare mutations in MAP7D3 have been tentatively linked to an X-linked form of myopathy (muscle disease) characterized by postural muscle atrophy (www.genecards.org). This association is based on genetic studies (e.g. an OMIM entry) but remains relatively under-characterized in the literature. The proposed connection is that altered MAP7D3 in muscle cells might disrupt microtubule stability and transport in muscle fibers, leading to muscle weakness. However, as of now, concrete evidence and mechanistic details on MAP7D3 in hereditary myopathies are limited. Further research is needed to confirm these links and to see if MAP7D3 plays a role in neurological disorders (since its paralogs are important in neurons) or other proliferative diseases.

Expert Perspectives and Ongoing Research

From a cell biology standpoint, MAP7D3 exemplifies how non-motor microtubule-associated proteins can exert wide-ranging influence by bridging structural and signaling roles. Experts note that MAP7 family proteins provide a “combinatorial MAP code” that specifies how microtubules interact with motors and other factors (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Anna Akhmanova and colleagues (2019) argue that MAP7D3 and its homologs act as critical cofactors that enable kinesin-1-driven transport in mammals (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). This was a significant conceptual advance – previously, kinesin regulation was thought to rely mostly on cargo adaptors and tubulin post-translational modifications, but the discovery of MAP7D3’s role showed that microtubule-bound activators are also required to unleash kinesin-1’s full activity (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). The structural basis of this activation is an active area of research. Recent cryo-electron microscopy studies of the MAP7–microtubule complex (though focusing on MAP7/ensconsin) have begun to visualize how the MAP7 MT-binding domain sits on the microtubule and might interact with motor domains (pmc.ncbi.nlm.nih.gov). Given MAP7D3’s higher affinity for kinesin, future structural work may examine the MAP7D3–kinesin complex specifically to design ways to modulate it.

In cancer research, the link between microtubule stability and metastasis via MAP7D3 is gaining attention. Microtubule stability can affect cell stiffness, migration, and even the success of anti-microtubule chemotherapy. Thus, scientists are viewing MAP7D3 as part of the cytoskeletal changes in metastatic cancer cells. Oncologists have pointed out that targeting microtubule regulators like MAP7D3 could synergize with existing microtubule-targeting drugs (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). For instance, inhibiting MAP7D3 might make tumor cells more vulnerable to lower doses of taxanes (like docetaxel) by removing a stabilizing factor and by reducing drug-resistance markers (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). However, because MAP7D3 is also important in normal dividing cells (e.g., for spindle stability), any therapeutic strategy would need to achieve a cancer-specific window. Ongoing studies are likely examining MAP7D3 expression in other cancers (such as lung or colon cancers) and whether it correlates with metastasis or drug resistance there as well.

Another frontier is understanding how MAP7D3 is regulated. There is evidence that MAP7D3 levels fluctuate with the cell cycle and possibly by signaling pathways. For example, MAP7 (ensconsin) is phosphorylated during mitosis to detach it from microtubules (pmc.ncbi.nlm.nih.gov) – it would be interesting to see if MAP7D3 is similarly regulated by phosphorylation or other modifications. A 2018 report by Kikuchi et al. (EMBO Rep 2018) indicated that MAP7D1 (and MAP7) can form a feedback loop with Wnt5a/Dishevelled signaling to facilitate cytoskeletal remodeling (pmc.ncbi.nlm.nih.gov). It remains to be determined if MAP7D3 also intersects with signaling networks (e.g., the reduction of Rac1 activity upon MAP7D3 knockdown in TNBC cells suggests an indirect link between MAP7D3 and actin cytoskeleton signaling (pmc.ncbi.nlm.nih.gov)). Such crosstalk could mean MAP7D3 is responsive to extracellular cues that promote metastasis (like chemokines or growth factors that also activate Rac1).

Conclusion

MAP7D3 (Mdp3) is a multifaceted microtubule-associated protein that plays a crucial role in maintaining microtubule stability, facilitating motor-based transport, and ensuring proper cell division. It acts as a scaffold and regulator on microtubules – on one hand anchoring and stabilizing the microtubule filaments, and on the other hand recruiting and modulating key enzymes (like motors and deacetylases) on those filaments. Through these actions, MAP7D3 influences cell structure, intracellular trafficking, and cell proliferation. The current understanding, bolstered by recent studies (2019–2023), has elevated MAP7D3 from a relatively obscure MAP to an important player in cancer progression. In triple-negative breast cancer, in particular, MAP7D3 emerges as an indicator of aggressive disease and a potential Achilles’ heel for therapeutic intervention (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). As research continues, scientists are unraveling how MAP7D3’s microtubule-binding domains and protein partners contribute to its function, and how this knowledge can be harnessed. The latest findings encourage a deeper exploration of MAP7D3 in both normal physiology (such as neuronal transport or muscle function) and disease states. Given its central role in microtubule dynamics and transport, MAP7D3 represents a nexus between the cytoskeletal infrastructure and cellular behavior, making it an exciting subject for further biochemical and clinical research.

References: Publications cited above include primary research articles and reviews from 2011–2023, such as Sun et al. 2011 (Cell Cycle), Yadav et al. 2014 (PLoS One), Kwon et al. 2016 (J. Cell Sci.), Hooikaas et al. 2019 (J. Cell Biol.), Tala et al. 2014 (Theranostics), and Kuo et al. 2023 (Biology Direct), among others. These provide experimental evidence for MAP7D3’s molecular functions (pmc.ncbi.nlm.nih.gov) (pubmed.ncbi.nlm.nih.gov), its role in spindle dynamics (pubmed.ncbi.nlm.nih.gov), interaction with HDAC6 (journals.plos.org), activation of kinesin-1 (pmc.ncbi.nlm.nih.gov), and its involvement in cancer cell metastasis and drug resistance (pmc.ncbi.nlm.nih.gov) (pmc.ncbi.nlm.nih.gov). Each of the above findings is supported by specific studies (see inline citations) with DOI-linked references for further reading.

Citations

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  16. AnnotationURLCitation(end_index=5115, start_index=4927, title='Microtubule Stabilization by Mdp3 Is Partially Attributed to Its Modulation of HDAC6 in Addition to Its Association with Tubulin and Microtubules | PLOS One', type='url_citation', url='https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0090932#:~:text=interaction%20of%20Mdp3%20with%20histone,its%20regulation%20of%20HDAC6%20activity')
  17. AnnotationURLCitation(end_index=5550, start_index=5371, title='Microtubule stabilization by Mdp3 is partially attributed to its modulation of HDAC6 in addition to its association with tubulin and microtubules - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/24614595/#:~:text=Immunoblotting%20and%20immunofluorescence%20microscopy%20showed,the%20activity%20of%20HDAC6%20toward')
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  19. AnnotationURLCitation(end_index=6018, start_index=5830, title='Microtubule Stabilization by Mdp3 Is Partially Attributed to Its Modulation of HDAC6 in Addition to Its Association with Tubulin and Microtubules | PLOS One', type='url_citation', url='https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0090932#:~:text=interaction%20of%20Mdp3%20with%20histone,its%20regulation%20of%20HDAC6%20activity')
  20. AnnotationURLCitation(end_index=6366, start_index=6178, title='Microtubule Stabilization by Mdp3 Is Partially Attributed to Its Modulation of HDAC6 in Addition to Its Association with Tubulin and Microtubules | PLOS One', type='url_citation', url='https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0090932#:~:text=interaction%20of%20Mdp3%20with%20histone,its%20regulation%20of%20HDAC6%20activity')
  21. AnnotationURLCitation(end_index=6565, start_index=6367, title='Microtubule Stabilization by Mdp3 Is Partially Attributed to Its Modulation of HDAC6 in Addition to Its Association with Tubulin and Microtubules | PLOS One', type='url_citation', url='https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0090932#:~:text=Moreover%2C%20depletion%20of%20Mdp3%20dramatically,its%20regulation%20of%20HDAC6%20activity')
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  26. AnnotationURLCitation(end_index=8961, start_index=8793, title='DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/27284004/#:~:text=decreased%20spindle%20stability%20and%20resulted,the%20DDA3%20complex%20orchestrates%20MT')
  27. AnnotationURLCitation(end_index=9266, start_index=9115, title='DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/27284004/#:~:text=MTs%20are%20poorly%20understood,the%20DDA3%20complex%20orchestrates%20MT')
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  30. AnnotationURLCitation(end_index=10890, start_index=10760, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=Monroy%20et%20al,terminal%20domain%20of%20MAP7')
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  37. AnnotationURLCitation(end_index=12847, start_index=12716, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=enhanced%20accumulation%20on%20MTs%20in,binding')
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  42. AnnotationURLCitation(end_index=14352, start_index=14228, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=C,as%20it%20moves%20along%20microtubules')
  43. AnnotationURLCitation(end_index=14580, start_index=14444, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=Hooikaas%20et%20al,stalk%20region%20of%20the%20motor')
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  45. AnnotationURLCitation(end_index=15048, start_index=14924, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=N,as%20it%20moves%20along%20microtubules')
  46. AnnotationURLCitation(end_index=15323, start_index=15199, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=N,as%20it%20moves%20along%20microtubules')
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  48. AnnotationURLCitation(end_index=15920, start_index=15763, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=end%E2%80%93shifted%20distribution%20of%20K560%2C%20we,4%2C%20A%20and%20B')
  49. AnnotationURLCitation(end_index=16534, start_index=16375, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=established%20to%20be%20positive%20regulators,terminal%20domain%20of%20MAP7')
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  52. AnnotationURLCitation(end_index=17449, start_index=17339, title='MAP7D3 Gene - GeneCards | MA7D3 Protein | MA7D3 Antibody', type='url_citation', url='https://www.genecards.org/cgi-bin/carddisp.pl?gene=MAP7D3#:~:text=,MA7D3_HUMAN%2CQ8IWC1')
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  56. AnnotationURLCitation(end_index=18636, start_index=18492, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=Monroy%20et%20al,Additional%20regions%20with%20MT%20affinity')
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  59. AnnotationURLCitation(end_index=19650, start_index=19486, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=to%20drive%20cell%20migration%20and,TNBC%20progression%20that%20inhibition%20of')
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  63. AnnotationURLCitation(end_index=20894, start_index=20785, title='Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis', type='url_citation', url='https://www.thno.org/v04p1052.htm#:~:text=malignancy,the%20management%20of%20this%20disease')
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  70. AnnotationURLCitation(end_index=23061, start_index=22952, title='Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis', type='url_citation', url='https://www.thno.org/v04p1052.htm#:~:text=malignancy,the%20management%20of%20this%20disease')
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  73. AnnotationURLCitation(end_index=24241, start_index=24081, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=animal%20study%20showed%20that%20the,outcomes%20of%20patients%20with%20TNBC')
  74. AnnotationURLCitation(end_index=24538, start_index=24395, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=MAP7D3%20expression%20was%20consistently%20upregulated,The')
  75. AnnotationURLCitation(end_index=24942, start_index=24773, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=cells%20in%20the%20orthotopic%20breast,This%20finding%20emphasizes%20the%20potential')
  76. AnnotationURLCitation(end_index=25116, start_index=24943, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=MAP7D3%20using%20multiple%20clinical%20datasets,biomarker%20for%20patients%20with%20TNBC')
  77. AnnotationURLCitation(end_index=25450, start_index=25285, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=to%20analyze%20the%20TCGA%20breast,based%20experiments%20%28Fig.%C2%A0%2019G%20J')
  78. AnnotationURLCitation(end_index=25798, start_index=25647, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=Our%20findings%20revealed%20that%20MAP7D3,vein%20injection%20mouse')
  79. AnnotationURLCitation(end_index=25942, start_index=25799, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=MAP7D3%20expression%20was%20consistently%20upregulated,The')
  80. AnnotationURLCitation(end_index=26386, start_index=26249, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=colony,MAP7D3%20drastically%20reduced%20TNBC%20tumor')
  81. AnnotationURLCitation(end_index=26546, start_index=26387, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=chemo%20drugs%20for%20TNBC%20patients,our%20study%20provides%20the%20first')
  82. AnnotationURLCitation(end_index=26896, start_index=26736, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=animal%20study%20showed%20that%20the,outcomes%20of%20patients%20with%20TNBC')
  83. AnnotationURLCitation(end_index=27006, start_index=26897, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=gemcitabine%20%28Fig,Our')
  84. AnnotationURLCitation(end_index=27313, start_index=27144, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=cells%20in%20the%20orthotopic%20breast,This%20finding%20emphasizes%20the%20potential')
  85. AnnotationURLCitation(end_index=27475, start_index=27314, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=highlighting%20its%20value%20as%20a,biomarker%20for%20patients%20with%20TNBC')
  86. AnnotationURLCitation(end_index=27857, start_index=27684, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=MAP7D3%20using%20multiple%20clinical%20datasets,biomarker%20for%20patients%20with%20TNBC')
  87. AnnotationURLCitation(end_index=27994, start_index=27858, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=chemotherapy%20as%20first,Previous%20studies%20have')
  88. AnnotationURLCitation(end_index=28274, start_index=28142, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=survival%20outcomes%20of%20patients%20with,TNBC')
  89. AnnotationURLCitation(end_index=28445, start_index=28275, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=Our%20investigation%20has%20provided%20new,for%20overcoming%20drug%20resistance%20and')
  90. AnnotationURLCitation(end_index=29001, start_index=28829, title='MAP7D3 Gene - GeneCards | MA7D3 Protein | MA7D3 Antibody', type='url_citation', url='https://www.genecards.org/cgi-bin/carddisp.pl?gene=MAP7D3#:~:text=with%20MAP7D3%20include%20Scapuloperoneal%20Myopathy,of%20this%20gene%20is%20MAP7D1')
  91. AnnotationURLCitation(end_index=30116, start_index=29957, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=established%20to%20be%20positive%20regulators,terminal%20domain%20of%20MAP7')
  92. AnnotationURLCitation(end_index=30291, start_index=30117, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=proteins%20strongly%20interacts%20with%20MTs%2C,flies%2C%20ensconsin%20is%20an%20essential')
  93. AnnotationURLCitation(end_index=30581, start_index=30445, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=Hooikaas%20et%20al,stalk%20region%20of%20the%20motor')
  94. AnnotationURLCitation(end_index=30711, start_index=30582, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=found%20that%20all%20four%20mammalian,binding')
  95. AnnotationURLCitation(end_index=31144, start_index=31014, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=Monroy%20et%20al,terminal%20domain%20of%20MAP7')
  96. AnnotationURLCitation(end_index=31319, start_index=31145, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=proteins%20strongly%20interacts%20with%20MTs%2C,flies%2C%20ensconsin%20is%20an%20essential')
  97. AnnotationURLCitation(end_index=31780, start_index=31617, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=MAP7D1%2C%20MAP7D2%2C%20and%20MAP7D3,flies%2C%20ensconsin%20is%20an%20essential')
  98. AnnotationURLCitation(end_index=32574, start_index=32396, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=Mechanistically%2C%20inhibition%20of%20MAP7D3%20could,TNBC%20population%2C%20and%20its%20high')
  99. AnnotationURLCitation(end_index=32716, start_index=32575, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=chemotherapy%20as%20first,19%5D.%20By%20analyzing%20CICs')
  100. AnnotationURLCitation(end_index=33042, start_index=32905, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=colony,MAP7D3%20drastically%20reduced%20TNBC%20tumor')
  101. AnnotationURLCitation(end_index=33202, start_index=33043, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=chemo%20drugs%20for%20TNBC%20patients,our%20study%20provides%20the%20first')
  102. AnnotationURLCitation(end_index=33963, start_index=33812, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=We%20next%20attempted%20to%20generate,and%20MAP7D3%20was%20reported')
  103. AnnotationURLCitation(end_index=34394, start_index=34254, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=mitotic%20spindle%20,family%20is%20involved%20in%20TNBC')
  104. AnnotationURLCitation(end_index=34766, start_index=34622, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=The%20dynamics%20of%20microtubule%20,related%20traits%20and')
  105. AnnotationURLCitation(end_index=35984, start_index=35811, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=MAP7D3%20using%20multiple%20clinical%20datasets,biomarker%20for%20patients%20with%20TNBC')
  106. AnnotationURLCitation(end_index=36155, start_index=35985, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=our%20investigation%20of%20paired%20primary,based%20experiments%20%28Fig.%C2%A01G%20J')
  107. AnnotationURLCitation(end_index=37291, start_index=37133, title='C-Terminal Region of MAP7 Domain Containing Protein 3 (MAP7D3) Promotes Microtubule Polymerization by Binding at the C-Terminal Tail of Tubulin - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC4057234/#:~:text=MAP7%20domain%20containing%20protein%203,we%20found%20that%20MAP7%20domain')
  108. AnnotationURLCitation(end_index=37443, start_index=37292, title='DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/27284004/#:~:text=MTs%20are%20poorly%20understood,the%20DDA3%20complex%20orchestrates%20MT')
  109. AnnotationURLCitation(end_index=37625, start_index=37474, title='DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle to control minus-end spindle dynamics - PubMed', type='url_citation', url='https://pubmed.ncbi.nlm.nih.gov/27284004/#:~:text=MTs%20are%20poorly%20understood,the%20DDA3%20complex%20orchestrates%20MT')
  110. AnnotationURLCitation(end_index=37844, start_index=37650, title='Microtubule Stabilization by Mdp3 Is Partially Attributed to Its Modulation of HDAC6 in Addition to Its Association with Tubulin and Microtubules | PLOS One', type='url_citation', url='https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0090932#:~:text=expression%20significantly%20reduced%20the%20level,the%20activity%20of%20HDAC6%20toward')
  111. AnnotationURLCitation(end_index=37999, start_index=37870, title='MAP7 family proteins regulate kinesin-1 recruitment and activation - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC6446838/#:~:text=found%20that%20all%20four%20mammalian,binding')
  112. AnnotationURLCitation(end_index=38252, start_index=38067, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=MAP7D3%20expression%20was%20consistently%20upregulated,MAP7D3%20drastically%20reduced%20TNBC%20tumor')
  113. AnnotationURLCitation(end_index=38422, start_index=38253, title='MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression - PMC', type='url_citation', url='https://pmc.ncbi.nlm.nih.gov/articles/PMC10405500/#:~:text=cells%20in%20the%20orthotopic%20breast,This%20finding%20emphasizes%20the%20potential')