Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods.
Towards a proteome-scale map of the human protein-protein interaction network.
RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins.
Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells.
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
The interferon stimulated gene 54 promotes apoptosis.
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IFIT3 (ISG60) negatively regulates IFIT2 (ISG54)-mediated apoptosis
"In addition, ISG60 binding negatively regulates the apoptotic effects of ISG54"
Next-generation sequencing to generate interactome datasets.
IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.
IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
An inter-species protein-protein interaction network across vast evolutionary distance.
Architecture of the human interactome defines protein communities and disease networks.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Expression of IFN-induced genes
Deep research summary for IFIT3
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IFIT3 stabilizes IFIT1 and enhances cap-0 RNA binding
"IFIT3 binding substantially extends the half-life of IFIT1 protein in cells"
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IFIT2-IFIT3 heterodimer targets short 5' UTR mRNAs
"The IFIT2-IFIT3 complex has been demonstrated to specifically target and inhibit translation of messenger RNAs with 5' untranslated regions shorter than approximately 50 nucleotides"
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IFIT3 bridges MAVS and TBK1
"IFIT3 has been demonstrated to stabilize MAVS interactions with the adaptor kinase TBK1"