epg-6 (Q86MP3) review notes

Deep research: just deep-research-falcon worm epg-6 was attempted (2026-10-08) but the
falcon provider timed out and perplexity was unavailable, so no deep-research file was
produced. The review is based on cached publications, the UniProt record and PubMed searches.

Key facts

• WD40 PROPPIN of the WIPI3/WIPI4 (yeast Hsv2) group PMID:30871075.
• Binds PI3P and binds ATG-2 directly; with ATG-2 drives omegasome-to-autophagosome progression PMID:21802374.
• In vitro also binds PI5P (strongly), PI4P and PI(3,5)P2 (weakly) [file:worm/epg-6/epg-6-uniprot.txt].
• Human counterpart: WIPI4 binds one tip of ATG2A PMID:30185561.
• epg-6 mutants are long-lived despite an autophagy block, suggesting an autophagy-independent role PMID:30871075.

Decisions

• PI3P binding and adaptor activity are core MFs; other phosphoinositide binding rows kept as non-core.
• GO:0034045 (obsolete) rows modified to GO:7770114 phagophore membrane (matching human ATG2A review).
• protein binding (IPI with ATG-2) modified to protein-macromolecule adaptor activity.
• NEW: GO:0062079 ATG2-ATG18 complex (direct binding, IPI).