Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Global analysis of protein localization in budding yeast.
Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding.
-
Rot1 is an ER-lumen-facing membrane protein that cooperates with Kar2/BiP.
"Rot1p was found to be an essential, ER-localized membrane protein facing the lumen."
Causal links between protein folding in the ER and events along the secretory pathway.
Rot1 plays an antagonistic role to Clb2 in actin cytoskeleton dynamics throughout the cell cycle.
Saccharomyces cerevisiae Rot1 is an essential molecular chaperone in the endoplasmic reticulum.
-
Rot1 functions as an ER molecular chaperone.
"Recombinant Rot1 exhibited antiaggregation activity in vitro, which was partly impaired by a temperature-sensitive rot1-2 mutation. In vivo, the rot1-2 mutation caused accelerated degradation of five proteins in the secretory pathway via ER-associated degradation,"
The essential endoplasmic reticulum chaperone Rot1 is required for protein N- and O-glycosylation in yeast.
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.
Cell wall integrity modulates RHO1 activity via the exchange factor ROM2.
UniProt entry for ROT1
-
UniProt summarizes ROT1 as an ER membrane protein involved in protein folding machinery.
"Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis."
Falcon deep research report for ROT1
-
Falcon synthesis supports Rot1 as an ER chaperone/assembly factor linked to glycoprotein maturation.
"Rot1's primary function is best described as an ER chaperone/assembly factor required for efficient glycosylation rather than a catalytic enzyme with a discrete small-molecule substrate."
PANTHER family PTHR28090 ROT1 metadata