Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome
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Original identification of EIF3E as the p48 subunit of human eIF3
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Interaction with EIF3A demonstrated
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Ubiquitous tissue expression
Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies
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EIF3E interacts with TRIM27 (Ret finger protein) and EIF3C
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Nuclear and cytoplasmic localization demonstrated by immunofluorescence
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Co-localization with PML bodies in nucleus
eIF3: a versatile scaffold for translation initiation complexes
Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry
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Mass spectrometry identification of all 13 eIF3 subunits
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EIF3E confirmed as integral component
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N-terminal acetylation of EIF3E
Human INT6/eIF3e is required for nonsense-mediated mRNA decay
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EIF3E is specifically required for NMD
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EIF3E interacts with CBP80 and UPF2
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EIF3E functions in pioneer round translation
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EIF3E knockdown inhibits NMD without affecting general translation
Reconstitution reveals the functional core of mammalian eIF3
Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3
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Complete eIF3 subunit interaction map
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EIF3E is part of module C with EIF3C, EIF3D, EIF3K, EIF3L
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EIF3E interacts directly with EIF3B, EIF3D, EIF3K, EIF3L
Architecture of human translation initiation factor 3
Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome
eIF3 targets cell-proliferation messenger RNAs for translational activation or repression
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eIF3 selectively regulates translation of specific mRNAs
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eIF3 can both activate and repress translation of target mRNAs
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c-Jun mRNA translation is activated by eIF3
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BTG1 mRNA translation is repressed by eIF3
Towards a proteome-scale map of the human protein-protein interaction network
Mammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulation
Large-scale mapping of human protein-protein interactions by mass spectrometry
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3
Subunit architecture of multiprotein assemblies determined using restraints from gas-phase measurements
Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium
Toward an understanding of the protein interaction network of the human liver
Global landscape of HIV-human protein complexes
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
A proteome-scale map of the human interactome network
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
Architecture of the human interactome defines protein communities and disease networks
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
A reference map of the human binary protein interactome
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
OpenCell: Endogenous tagging for the cartography of human cellular organization
Systematic identification of post-transcriptional regulatory modules
Mechanisms of translational regulation by a human eIF5-mimic protein
E-cadherin interactome complexity and robustness resolved by quantitative proteomics
Defining the membrane proteome of NK cells
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a closed-loop conformation
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA
Formation of translation initiation complexes containing mRNA that does not circularize
eIF2-GTP is hydrolyzed, eIFs are released
eIF3 and eIF1A bind to the 40S subunit
Formation of the 43S pre-initiation complex
Deep research on EIF3E function