Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals.
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Punt-containing receptor complexes positively activate SMAD signaling.
"dSMAD2 is phosphorylated by ATR-I and PUNT, but not by activated THICK VEINS, and translocates to the nucleus upon activation."
Mutations that alter the morphology of the malpighian tubules in Drosophila.
Organ formation in Drosophila: specification and morphogenesis of the salivary gland.
In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis.
TGF-beta signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain.
Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo.
Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo.
A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila trachea.
The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing.
The Drosophila type II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFbeta family signaling pathways.
Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons.
The metalloprotease tolloid-related and its TGF-beta-like substrate Dawdle regulate Drosophila motoneuron axon guidance.
The divergent TGF-beta ligand Dawdle utilizes an activin pathway to influence axon guidance in Drosophila.
Distinct signaling of Drosophila Activin/TGF-beta family members.
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Punt is a shared type II receptor kinase for activin and BMP signaling.
"Only Drosophila Activin (dACT) and the Activin-like ligand Dawdle (DAW) signal through BABO in combination with the type II receptor PUNT and activate dSMAD2."
The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon.
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Punt is a type II activin-family receptor.
"In cell culture, Dawdle signaling is active in the presence of the Type-II receptor Punt but not Wit, demonstrating that the Type-II receptor also contributes to the specificity of the signaling complex."
Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligand.
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Punt contributes to signaling that promotes neuromuscular junction development.
"Here we show that NMJ glia release the TGF-β ligand Maverick (Mav), which likely activates the muscle activin-type receptor Punt to potently modulate Gbb-dependent retrograde signaling and synaptic growth."
Transforming growth factor β/activin signaling functions as a sugar-sensing feedback loop to regulate digestive enzyme expression.
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Punt signaling participates in the cellular response to dietary sugars.
"Dawdle then acts via circulation to activate TGF-β/Activin signaling in the midgut, culminating in the repression of digestive enzymes that are highly expressed during starvation."
Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control.
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Punt contributes to endocrine control of carbohydrate balance.
"RNAi stocks targeting Babo and Punt (Put), which encode a type I and II TGF-β receptors, respectively, were among the reagents exerting the greatest suppression of AKH-induced hyperglycemia in the primary RNAi screen"
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Punt-dependent signaling promotes AKH-associated glycogen mobilization.
"AKH signaling in the fly fat body regulates circulating carbohydrate levels via both glycogen breakdown and glucose/trehalose production."
Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic <i>Drosophila</i> retina.
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Punt participates in retinal signaling that establishes R8 subtype.
"We find that the Activin receptor Baboon is required in R8 to receive non-redundant signaling from the three Activin ligands, activating the transcription factor dSmad2."
Alternative cleavage of the bone morphogenetic protein (BMP), Gbb, produces ligands with distinct developmental functions and receptor preferences.
A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila.
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Punt occupies tissue-dependent plasma-membrane domains.
"In follicle cells of the egg chamber, both Punt and Wit were indiscriminately distributed basolaterally and apically"
Heterodimerization-dependent secretion of bone morphogenetic proteins in Drosophila.
An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo.
Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family.
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Punt is a shared type II receptor kinase for activin and BMP signaling.
"punt will bind BMP2 in concert with tkv or sax, forming complexes with these receptors."
Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.
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The activin receptor activity is specifically type II.
"Atr-I binds activin efficiently when coexpressed with the distantly related Drosophila activin receptor Atr-II, with which it forms a heteromeric complex."
Identification of a Drosophila activin receptor.
Direct and long-range action of a DPP morphogen gradient.
Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure.
The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling.
Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp.
decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary.
Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila.
The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development.
Curated UniProt record for Drosophila put
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Punt uses ATP in its receptor-kinase catalytic domain.
"Reaction=L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl- [receptor-protein] + ADP + H(+);"
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Punt occupies tissue-dependent plasma-membrane domains.
"Highly restricted to the basolateral cell membrane in wing disc epithelial cells; basolateral localization is dependent on the BLT motif and on the AP-1 adapter protein complex"
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Punt-dependent signaling contributes to embryonic dorsal closure.
"Failure of dorsal closure resulting in a large hole in the dorsal cuticle (PubMed:7697719, PubMed:7697720, PubMed:9504926)."
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Punt is required for motoneuron axon guidance.
"Required in motoneurons for axon guidance or outgrowth of ISNb and SNa axons (PubMed:17119022)."
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Punt contributes to development of the embryonic tracheal system.
"Involved in dpp/BMP-like signaling during development of the embryonic gut tracheal system (PubMed:7697719, PubMed:7697720)."
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Dpp-receptor signaling supports primary tracheal branch morphogenesis.
"Tracheal dorsal branches fail to develop in parasegments 6 and 7 (PubMed:7697719)."
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Punt-dependent BMP signaling contributes to wing morphogenesis.
"Involved in adult wing development and wing- vein formation (PubMed:7697720)."
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Punt mutants have head-involution defects.
"Defects in head involution (PubMed:7697720)."
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Punt-dependent BMP signaling patterns the embryonic dorsal–ventral axis.
"Involved in dpp-signaling-dependent dorsoventral patterning of the epidermis during embryogenesis (PubMed:7697719, PubMed:7697720, PubMed:9504926)."
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Punt is a core BMP-pathway type II receptor.
"Activation by BMP-like ligands, including gbb and dpp, results in phosphorylation of the R-SMAD Mad (PubMed:18820452, PubMed:19766717)."
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Punt contributes to BMP-dependent wing-disc pattern formation.
"Required for dpp/BMP-like signaling involved in imaginal disc development (PubMed:9504926)."
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Punt contributes to development of adult-specific neurons.
"Involved in differentiation of dorsal cluster and ellipsoid body adult-specific neurons prior to metamorphosis (PubMed:16437159)."