Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
A map of the interactome network of the metazoan C. elegans.
Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis.
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B9 proteins (MKS-1, MKSR-1, MKSR-2) form a complex at the base of cilia
"we report that the C. elegans B9 proteins form a complex that localizes to the base of cilia"
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B9 proteins function redundantly with nephrocystins in ciliogenesis
"Mutations in the B9 genes do not overtly affect cilia formation unless they are in combination with a mutation in nph-1 or nph-4"
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Required for cilia and dendrite formation in amphid/phasmid sensory neurons
"the B9 proteins function redundantly with the nephrocystins to regulate the formation and/or maintenance of cilia and dendrites in the amphid and phasmid ciliated sensory neurons"
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.
Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins.
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All C. elegans B9 proteins localize to transition zones/basal bodies
"all Caenorhabditis elegans B9-domain-containing proteins, MKS-1 and MKS-1-related proteins 1 and 2 (MKSR-1, MKSR-2), localize to transition zones/basal bodies of sensory cilia"
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Subcellular localization is co-dependent between B9 proteins
"Their subcellular localization is largely co-dependent, pointing to a functional relationship between the proteins"
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Double/triple mks/mksr mutants show extended lifespan via abnormal insulin-IGF-I signaling
"we find genetic interactions between all double mks/mksr mutant combinations, manifesting as an increased lifespan phenotype, which is due to abnormal insulin-IGF-I signaling"
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No overt ciliary structure defects in single mutants
"single, double and triple C. elegans mks/mksr mutants do not display overt defects in ciliary structure, intraflagellar transport or chemosensation"
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis.
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MKS/MKSR/NPHP proteins localize specifically to the ciliary transition zone
"MKS/MKSR and NPHP proteins localize specifically to the ciliary TZ"
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Two functional modules (MKS and NPHP) cooperate in TZ function
"These TZ proteins functionally interact as members of two distinct modules, which together contribute to an early ciliogenic event"
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TZ proteins establish basal body membrane attachments and ciliary gate
"MKS/MKSR/NPHP proteins establish basal body/TZ membrane attachments before or coinciding with intraflagellar transport-dependent axoneme extension and subsequently restrict accumulation of nonciliary components within the ciliary compartment"
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Gate restricts accumulation of non-ciliary components
"subsequently restrict accumulation of nonciliary components within the ciliary compartment"
Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron.
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MKSR-2 localizes to dendrite terminus in AFD thermosensory neurons
"ciliary proteins help establish two contiguous, yet distinct cyclic GMP (cGMP) signaling compartments in Caenorhabditis elegans thermosensory AFD neurons"
A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
Deep research report on mksr-2