Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:40519748

Identification and characterization of short-chain dehydrogenase/reductase 3 (DHRS3) deficiency, a retinoic acid embryopathy of humans.

DHRS3 is the major embryonic enzyme reducing retinaldehyde (RAL) to retinol (ROL), opposing RDH10 and limiting excessive retinoic-acid synthesis; it acts in an ER-membrane complex with RDH10, and hypomorphic biallelic variants cause a retinoic-acid embryopathy with elevated RA and reduced retinol.

PMID:9705317

Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.

Original cloning and characterization of retSDR1 (DHRS3), an SDR that reduces all-trans-retinal with the substrate specificity of photoreceptor all-trans-retinol dehydrogenase; predicted a Rossmann fold for nucleotide (NADP) binding and an N-terminal membrane anchor.

Reactome:R-HSA-2187335

The retinoid cycle in cones (daylight vision)

Reactome:R-HSA-2465940

atRAL is reduced to atROL

Reactome:R-HSA-5419165

RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL