GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000041

Gene Ontology annotation based on UniPathway vocabulary mapping

GO_REF:0000044

Gene Ontology annotation based on UniProtKB Subcellular Location vocabulary mapping

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:22658674

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

PMID:22681889

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

PMID:28065601

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination.

ZNF598 is the ubiquitin ligase required for ribosomes to terminally stall on poly(A) sequences, and it monoubiquitinates the 40S protein eS10 as its primary target, initiating RQC.

PMID:28132843

ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation.

ZNF598 (with RACK1) mediates regulatory 40S ribosomal ubiquitylation required for mammalian RQC.

PMID:28685749

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

ZNF598 is an E3 ligase and RNA-binding protein that, using the E2 UBE2D3, triggers ubiquitination of ribosomal proteins to initiate RQC on poly(A) segments.

PMID:28757607

Ubiquitination of stalled ribosome triggers ribosome-associated quality control.

Establishes (in yeast) that Hel2/RQT1-mediated ubiquitination of uS10 triggers RQC; the orthologous activity in human is ZNF598.

PMID:30293783

ZNF598 Is a Quality Control Sensor of Collided Ribosomes.

The minimal unit engaged by ZNF598 is the collided di-ribosome; ZNF598 uses ribosome collisions as the proxy for stalling and ubiquitinates targets at the 40S-40S interface.

PMID:32099016

Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells.

ZNF598-mediated ubiquitination recruits the mammalian RQT/trigger complex that drives stalled-ribosome disassembly.

PMID:32579943

The ASC-1 Complex Disassembles Collided Ribosomes.

The ASC-1/RQT complex disassembles collided ribosomes downstream of ZNF598 ubiquitination.

PMID:32726578

GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.

ZNF598 is part of the 4EHP-GYF2 module (with EIF4E2 and GIGYF2) that inhibits translation initiation of defective mRNAs, acting as a protein-RNA adaptor.

PMID:33053355

4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.

ZNF598 interacts with GIGYF1 within the 4EHP-GYF module that mediates translation- coupled mRNA decay.

PMID:33581075

Live-cell imaging reveals kinetic determinants of quality control triggered by ribosome stalling.

Live-cell imaging of ZNF598-triggered RQC defines the kinetics of stalling-induced quality control.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

PMID:36302773

A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

ZNF598 catalyzes K63-linked polyubiquitination of uS10 on collided ribosomes to recruit the hRQT complex for subunit dissociation; in human cells eS10 is preferentially monoubiquitinated.

PMID:36931259

A central chaperone-like role for 14-3-3 proteins in human cells.

Reactome:R-HSA-9948299

Reactome: rescue of stalled ribosome (ZNF598)

Reactome:R-HSA-9948301

Reactome: ZNF598 ubiquitin transferase activity / cytosol

Reactome:R-HSA-9948317

Reactome: ZNF598 cytosol localization

file:human/ZNF598/ZNF598-uniprot.txt

UniProt entry Q86UK7 (ZNF598_HUMAN), E3 ubiquitin-protein ligase ZNF598

RING E3 ligase and ribosome collision sensor that binds collided di-ribosomes and monoubiquitinates eS10/uS3 and K63-polyubiquitinates uS10 (with E2 UBE2D3) to recruit the RQT complex and initiate RQC; also a 4EHP-GYF2 adapter and RNA-binding protein; cytosolic.