Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans.
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GPR-1/2 bind GDP-Galpha(i/o) via their GoLoco motif, associate with LIN-5 and depend on it for spindle and cortical localization.
"GPR-1/GPR-2 contain a GoLoco/GPR motif that mediates interaction with GDP-bound Galpha(i/o)"
Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.
Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo.
LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.
Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division.
A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans.
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Uses gpr-1/2 RNAi as a tool to abolish astral pulling forces; corroborates the pulling-force requirement but provides no new GPR-1 function.
"We used a dsRNA that depletes two highly homologous G-protein regulators, GPR-1 and GPR-2, which are required for the production of astral pulling forces"
Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans.
Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning.
A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning.
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.
NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha.
LET-99 inhibits lateral posterior pulling forces during asymmetric spindle elongation in C. elegans embryos.
Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos.