GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

PMID:18066067

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.

Human HsAkirin1 and HsAkirin2 show NLS-dependent nuclear localization in HeLa cells.
Immune rescue/essentiality experiments principally establish Akirin2 functions; the tested Akirin1-null cytokine responses were normal.

PMID:23516508

Myostatin suppression of Akirin1 mediates glucocorticoid-induced satellite cell dysfunction.

Direct Akirin1 overexpression improves C2C12 proliferation and differentiation under the tested dexamethasone conditions; this does not determine the sign in every cell state.

PMID:34711951

AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

The study concerns AKIRIN2-dependent nuclear proteasome import, not evidence for an AKIRIN1 import annotation.

PMID:25416956

A proteome-scale map of the human interactome network.

IntAct confirms human AKIRIN1-GOPC binary two-hybrid evidence from the exact paper.

PMID:19406121

Akirin1 (Mighty), a novel promyogenic factor regulates muscle regeneration and cell chemotaxis.

Mouse Akirin1 regulates macrophage/myoblast chemotaxis and lamellipodia through PI3K-dependent actin reorganization.

PMID:18255059

Mighty is a novel promyogenic factor in skeletal myogenesis.

Mighty overexpression promotes earlier cell-cycle withdrawal and enhanced terminal myogenesis in C2C12 cultures.

PMID:40211850

CircEPDR1 regulates proliferation and differentiation of goat skeletal muscle satellite cells through miR-345-3p/Akirin1 axis.

Direct goat Akirin1 overexpression reduces proliferation readouts while increasing myogenic differentiation.

PMID:30746755

Role of Akirin1 in the regulation of skeletal muscle fiber-type switch.

Akirin1 regulates a muscle promoter reporter and influences muscle fiber composition despite no gross knockout phenotype.

PMID:39856124

miR-224 activates cancer-associated fibroblasts to enhance lung cancer cell migration and invasion by targeting Akirin1.

Mouse Akirin1 perturbation in fibroblasts affects cancer-cell behavior in coculture; assay identity differs from macrophage chemotaxis.

file:human/AKIRIN1/AKIRIN1-primary-and-phylogeny-scope.md

AKIRIN1 primary evidence and phylogenetic scope

Q9H9L7 inherits the positive muscle/motility assertions from PTN002665250 and nuclear/transcriptional assertions from PTN000329080.
GO:1902725 concerns satellite-cell identity and is compatible with enhanced terminal myogenesis.
The generic binary-binding evidence does not justify protein-containing complex binding.

file:human/AKIRIN1/AKIRIN1-deep-research-falcon.md

Research Report: Human AKIRIN1 (UniProt Q9H9L7; Akirin-1/Mighty) — functional annotation

The report emphasizes a promyogenic nuclear cofactor role, while treating detailed immune mechanisms mainly as family/Akirin2 evidence.
Disease/fertility associations do not establish a new function; the report is a synthesis, not independent experimental proof.

file:human/AKIRIN1/AKIRIN1-uniprot.txt

UniProt entry Q9H9L7 (AKIRIN1_HUMAN)

Human AKIRIN1 is Q9H9L7; the record identifies mouse Q99LF1 as Akirin1 functional evidence.