Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte.
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rab-7 RNAi mislocalizes internalized yolk into enlarged peripheral vesicles without strongly reducing uptake, consistent with a block in a later endocytic step.
"We have blocked expression of Ce-rab7 by RNAi and observed accumulation of YP170::GFP in large peripheral vesicles of the oocyte"
The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans.
Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic.
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SAND-1/Mon1 is required for RAB-7 function at the early-to-late endosome transition but not at lysosomes.
"SAND-1 is essential for RAB-7 function at the transition from early to late endosomes, but not for RAB-7 function at lysosomes"
An endocytic pathway as a target of tubby for regulation of fat storage.
Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells.
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RAB-7 is recruited to phagosomes downstream of CED-1 and is essential for recruitment and fusion of lysosomes to phagosomes; the GDP-locked T23N mutant does not rescue.
"whose function is essential for promoting the recruitment and fusion of lysosomes to phagosomes"
AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling.
TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans.
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Recombinant RAB-7 hydrolyses GTP and TBC-2 weakly accelerates this; TBC-2 membrane localization requires RAB-7.
"TBC-2 localizes to endosomes with RAB-7, requires RAB-7 for membrane localization"
Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation.
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RAB-7 mediates fusion of lysosomes to phagosomes after RAB-14 and UNC-108 recruit them.
"RAB-14 and UNC-108 recruit lysosomes, whereas RAB-7 mediates fusion of lysosomes to phagosomes"
The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans.
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RAB-7 marks late endosomes in the intestine; gbf-1 RNAi causes RAB-7-positive late endosomes to aggregate and tubulate.
"RAB-7-positive late endosomes were more abundant and formed aggregates and tubular structures"
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
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RAB-7 appears on maturing endosomes as PtdIns3P declines; rab-7 acts in parallel with sorf-1/sorf-2 to limit endosomal PtdIns3P.
"Thus, conversion of early to late endosomes is marked by a strong decrease or turnover of endosomal PtdIns3P and appearance of RAB-7."
The HEAT repeat protein HPO-27 is a lysosome fission factor.
UniProtKB Q23146 (rab-7) record