Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
UniProtKB Q8WWF8: human CAPSL sequence and curated features
Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy.
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Endothelial-specific Capsl knockout in mouse causes FEVR-like retinal vascular defects, and CAPSL knockdown in human retinal microvascular endothelial cells impairs proliferation and migration and lowers MYC protein but not MYC mRNA.
"Notably, the depletion of CAPSL significantly decreased the protein level of MYC, rather than the mRNA level in HRECs (Figure 7G)."
Calcyphosine-like (CAPSL) is regulated in Multiple Symmetric Lipomatosis and is involved in Adipogenesis.
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Capsl knockout 3T3-L1 cells show enhanced adipogenic differentiation, while overexpressing cells fail to accumulate lipid properly.
"CapslKO cells showed enhanced propensity for differentiation, while CapslOE cells showed no proper lipid accumulation"
Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family.
Falcon deep-research report on human CAPSL
Structure of the mammalian ciliary transition zone microtubule doublet
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Cryo-ET of bovine tracheal cilia identifies CAPSL as a lumenal microtubule inner protein of the transition-zone doublet that forms a pseudo-helical spiral and stabilizes microtubules in vitro.
"We identify the calcium-binding protein CAPSL as a lumenal MIP that forms a pseudo-helical spiral and stabilizes microtubules"