Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Forskolin cooperating with growth factor on generation of dopaminergic neurons from human fetal mesencephalic neural progenitor cells.
Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation.
Expression survey of genes critical for tooth development in the human embryonic tooth germ.
Involvement of FGF and BMP family proteins and VEGF in early human kidney development.
Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice.
BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors.
Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal.
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region.
Receptor specificity of the fibroblast growth factor family.
The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells.
PI3K-containing complexes phosphorylate PIP2 to PIP3
Activated FGFR1 mutants and fusions bind PLCG1
Activated FGFR1 mutants and fusions phosphorylate PLCG1
p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions
Autocatalytic phosphorylation of FGFR4
Autocatalytic phosphorylation of FGFR3b
Autocatalytic phosphorylation of FGFR3c
Autocatalytic phosphorylation of FGFR2c
Autocatalytic phosphorylation of FGFR1c
Autocatalytic phosphorylation of FGFR3c P250R mutant
FGFR3c P250R mutant binds to ligand with enhanced affinity
FGFR1c P252X mutants bind ligand with enhanced affinity
Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
FGFR2c mutants bind an expanded range of ligands
Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
Activated FGFR2 phosphorylates PLCG1
p-4Y-PLCG1 dissociates from activated FGFR3
Activated FGFR1 phosphorylates PLCG1
Activated FGFR4 phosphorylates PLCG1
p-4Y-PLCG1 dissociates from activated FGFR2
Activated FGFR2 binds PLCG1
Activated FGFR4 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR1
Activated FGFR1 binds PLCG1
p-4Y-PLCG1 dissociates from activated FGFR4
Activated FGFR3 phosphorylates PLCG1
Activated FGFR3 binds PLCG1
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 phosphorylates FRS2
Activated FGFR2 binds FRS2
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 binds SHC1
Activated FGFR2:p-SHC1 binds GRB2:SOS1
Activated FGFR2 phosphorylates SHC1
Activated FGFR3 phosphorylates FRS2
Activated FGFR3 binds FRS2
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3:pFRS binds GRB2:SOS1
Activated FGFR4 phosphorylates FRS2
Activated FGFR4 binds FRS2
Activated FGFR4:p-SHC1 binds GRB2:SOS1
Activated FGFR4 binds SHC1
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 phosphorylates SHC1
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2
Activated FGFR1 binds FRS2
Activated FGFR1 binds FRS3
Activated FGFR1 binds SHC1
Activated FGFR1 phosphorylates FRS2
Activated FGFR1 phosphorylates FRS3
Activated FGFR1 phosphorylates SHC1
Activated FGFR1:p-FRS bind to PPTN11
Activated FGFR1:p-FRS binds GRB2:SOS1
Activated FGFR1:p-FRS phosphorylates PPTN11
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1:p-SHC1 binds GRB2:SOS1
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 binds FRS3
Activated FGFR2 phosphorylates FRS3
Activated FGFR2 phosphorylates PPTN11
Activated FGFR2:p-FRS bind to PPTN11
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR2:pFRS binds GRB2:SOS1
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3 binds FRS3
Activated FGFR3 binds SHC1
Activated FGFR3 phosphorylates FRS3
Activated FGFR3 phosphorylates PPTN11
Activated FGFR3:p-FRS bind to PPTN11
Activated FGFR3 phosphorylates SHC1
Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3:p-SHC1 binds GRB2:SOS1
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4 binds FRS3
Activated FGFR4 phosphorylates FRS3
Activated FGFR4 phosphorylates PPTN11
Activated FGFR4:p-FRS bind to PPTN11
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR4:p-FRS binds GRB2:SOS1
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
CBL ubiquitinates FRS2 and FGFR1
p-CBL:GRB2 binds p-FRS2:activated FGFR1
CBL ubiquitinates FRS2 and FGFR2
CBL ubiquitinates FRS2 and FGFR3
CBL ubiquitinates FRS2 and FGFR4
FGFR1-associated PI3K phosphorylates PIP2 to PIP3
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
FGFR2-associated PI3K phosphorylates PIP2 to PIP3
FGFR3-associated PI3K phosphorylates PIP2 to PIP3
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
FGFR4-associated PI3K phosphorylates PIP2 to PIP3
p-CBL:GRB2 binds p-FRS2:activated FGFR2
p-CBL:GRB2 binds p-FRS2:activated FGFR3
p-CBL:GRB2 binds p-FRS2:activated FGFR4
p-4Y-PLCG1 dissociates from activated FGFR2 mutants
Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3 point and translocation mutants phosphorylate PLCG1
Activated FGFR3 point and translocation mutants bind PLCG1
Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants
Activated FGFR3 point, translocation and fusion mutants bind FRS2
Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR2 mutants phosphorylate FRS2
Activated FGFR1 mutants bind FRS2
Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR1 mutants phosphorylate FRS2
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR2 mutants phosphorylate PLCG1
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR2 mutants bind FRS2
Activated FGFR2 mutants bind PLCG1
Activated FGFR1 binds FLRT1,2,3
RAS GEFs promote RAS nucleotide exchange
Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain.
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FGF8b directly binds FGFR2c, and its isoform-specific N-terminal contact explains increased receptor affinity and organizer potency.
"we solved the crystal structure of FGF8b in complex with the "c" splice isoform of FGF receptor 2 (FGFR2c)."
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
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FGF activity depends on ligand-receptor specificity and heparan-sulfate cofactors.
"FGF signaling activity is regulated by the binding specificity of ligands and receptors and is modulated by extrinsic cofactors such as heparan sulfate proteoglycans."
The duration of Fgf8 isthmic organizer expression is key to patterning different tectal-isthmo-cerebellum structures.
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Sustained isthmic Fgf8 represses Otx2 in hindbrain and permits isthmus and cerebellum formation.
"One crucial role for sustained Fgf8 function is in repressing Otx2 in the hindbrain, thereby allowing the isthmus and cerebellum to form."
UniProt text export for human FGF8 (P55075)
Manual evidence and curation notes for human FGF8