Exact emitted record, retrieved 2026-09-10T14:34:36.311614+00:00.
Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons
NPI (CS 0; TAXON_CONSTRAINT_VIOLATION) for the composite statement, specifically its claim that rat PTK7 targets fly R1–R6 axons to the lamina. Q6AWJ9 is the homologous fly receptor Off-track, so this is a lineage-specific developmental overtransfer rather than a random unrelated-protein match. Generic adhesion, Plexin interaction and axon guidance are separately UNC for this rat product: homologous developmental signaling makes them plausible, but the fly paragraph does not establish each mechanism in rat. The demonstrated mammalian PTK7-Src-ROCK polarity mechanism is a different, independently supported claim. Donor record; PMID:24703874(https://pubmed.ncbi.nlm.nih.gov/24703874/).
The assessment concerns the selected accession A0A8I6ALM9. Other emitted outputs and evidence context.