dlg1 (Discs large 1, P31007) -- manual literature review

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Identity and domain architecture

• Drosophila dlg1 (CG1725) encodes Discs large, the founding MAGUK (membrane-associated
  guanylate kinase homolog). UniProt P31007: L27 (isoform S97 only), three PDZ domains, SH3, and
  a C-terminal guanylate kinase-like (GUK) domain; "Belongs to the MAGUK family" (UniProt).
• Two major isoform classes: DlgA (PSD-95-like) and DlgS97 (SAP97-like, adds an N-terminal L27)
  PMID:18171947.
• The GUK domain is a protein-interaction domain, not an enzyme. Ancestral reconstruction of the
  MAGUK GK protein-interaction domain (GKPID) shows the transition from enzyme to scaffold
  PMID:26740169.
  The Dlg GUK binds GukH and Pins, and is regulated by the adjacent SH3 domain
  PMID:19769408.

Epithelial polarity and septate junctions

• Dlg localizes to the septate junction (SJ) at the apicolateral membrane
  PMID:1651169.
• Dlg is required for SJ maintenance and apicobasal polarity, and is a neoplastic tumour
  suppressor PMID:8830775.
• Dlg acts with Scrib and Lgl (the Scrib module) PMID:10884224.
• Dlg stabilizes Scrib at the cortex PMID:32414916.
• Dlg is required at tricellular junctions and associates with Gliotactin there
  PMID:17032735.

Neuroblast asymmetric division and spindle orientation

• Dlg is required for cortical Lgl and basal determinant targeting
  PMID:11117748.
• Dlg links astral microtubules (via Khc-73) to cortical Pins/Galphai
  PMID:16377571.
• In induced-polarity S2 cells, phosphorylated Pins LINKER recruits Dlg, and the Dlg GK domain
  acts through Khc-73 PMID:19766567.
• Dlg acts in a pathway parallel to Canoe/Ran/Mud PMID:22024168.

Neuromuscular junction

• Dlg clusters Fas2 and Shaker through their C-termini PMID:9390515.
• Dlg stabilizes GluRIIB-containing receptors PMID:15638945.
• Dlg assembles the subsynaptic reticulum (SSR) PMID:27838296.
• PAR-1 phosphorylation controls Dlg postsynaptic targeting PMID:17224403.
• Dlg, GukH and Scrib form a synaptic complex PMID:11937021.
• DlgS97 is needed for adult behaviours (courtship, phototaxis, circadian activity) PMID:18171947
  and ethanol tolerance PMID:23145041.

Other reported phenotypes (indirect)

• Follicle cell patterning defects downstream of polarity loss PMID:19948068.
• miR-34 target; RNAi raises Diptericin in S2 cells PMID:27893816.