GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:RAMVA/RvY_13070/RvY_13070-bioinformatics/RESULTS.md

Bioinformatics analysis of Cu/Zn SOD paralogs in R. varieornatus

All 10 catalytic residues (Cu ligands, Zn ligands, disulfide cysteines) are preserved in RvY_00651 when aligned to human SOD1

PMID:37358501

Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1.

Structural and biochemical work on the related paralog RvSOD15 (PDB 7ypp/7ypr) cautions that subtle structural defects (electrostatic loop deletions, atypical Cu coordination) can render Cu/Zn SOD-fold paralogs catalytically divergent even when primary-sequence residues are preserved; this caveat applies broadly to the expanded R. varieornatus SOD gene family.

file:RAMVA/RvY_00651/RvY_00651-deep-research-falcon.md

Deep research report on RvY_00651 (Falcon/Edison Scientific Literature)

No primary publication directly characterizes RvY_00651 / A0A1D1UKR0; sequence-level annotation as a canonical Cu/Zn SOD is supported by 66 percent identity to human SOD1 plus full conservation of catalytic Cu/Zn ligands and disulfide cysteines, while the Sim 2023 structural caveats and the 2024 tardigrade antioxidant defense review (Sadowska-Bartosz 2024) keep open the possibility of paralog-specific functional divergence in this expanded gene family (R. varieornatus has approximately 17 SOD genes).