Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Distinct roles for CARMIL isoforms in cell migration.

Defining the membrane proteome of NK cells.

CARMIL2 is a novel molecular connection between vimentin and actin essential for cell migration and invadopodia formation.

Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2.

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.

The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.

Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.

A human immunodeficiency syndrome caused by mutations in CARMIL2.

Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency.