PGS1 (PEL1, YCL004W, P25578) notes

Identity

• CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGP synthase), EC 2.7.8.5; PLD superfamily (HKD) [UniProt:P25578].

Evidence

• PGS1 encodes the major PGP synthase; null lacks PGP synthase activity, PG and CL PMID:9545322
• Committed step of CL synthesis PMID:9545322.
• Mitochondrial localization PMID:9799363; activity in inner membrane PMID:3005242.

Curation decisions

• Core: GO:0008444; CL and PG biosynthesis; mitochondrial inner membrane (not in GOA; GOA has only mitochondrion).
• Cytosol RCA removed (conflicts with mitochondrion RCA from PHOS-PWY). catalytic activity IEA -> MODIFY.