Annotation inferences using phylogenetic trees

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans.

Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans.

gst-4 is a SKN-1 target induced during infection-associated ROS.

"The gst genes encode for glutathione-S-transferases, which are important for detoxifying reactive compounds by conjugating reduced glutathione to electrophilic centers"

file:worm/gst-4/gst-4-uniprot.txt

UniProtKB Q21355 (GST4_CAEEL) record

file:worm/gst-4/gst-4-deep-research-wormbase.md

WormBase gene description for gst-4 (worm)