Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.
A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin.
Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta.
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling.
The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.
The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP.
Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta.
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.
Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle.
Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules.
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.
A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors.
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity.
Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain.
The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions.
Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.
GSK3B polymorphisms alter transcription and splicing in Parkinson's disease.
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity.
Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.
GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta.
Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity.
PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners.
GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.
14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9.
Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.
Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans.
Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3.
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.
Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation.
Microtubule stabilization specifies initial neuronal polarization.
Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity.
p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.
Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion.
Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells.
Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma.
Identification of an antiapoptotic protein complex at death receptors.
Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization.
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.
Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases.
Glycogen synthase kinase 3: more than a namesake.
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion.
Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder.
GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells.
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.
The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1.
Vimentin is a novel AKT1 target mediating motility and invasion.
PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells.
ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin.
Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation.
Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling.
ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health.
Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis.
A directed protein interaction network for investigating intracellular signal transduction.
Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β.
Toward an understanding of the protein interaction network of the human liver.
Oncogenic function of DACT1 in colon cancer through the regulation of β-catenin.
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation.
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.
Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling.
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.
The importance of Wnt signalling for neurodegeneration in Parkinson's disease.
NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation through activated Akt.
Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
The protein interaction landscape of the human CMGC kinase group.
miR-346 regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the Wnt/β-catenin pathway.
The regulation and deregulation of Wnt signaling by PARK genes in health and disease.
Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β.
NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas.
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.
The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.
HN1 negatively influences the β-catenin/E-cadherin interaction, and contributes to migration in prostate cells.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
GSK3- and PRMT-1-dependent modifications of desmoplakin control desmoplakin-cytoskeleton dynamics.
FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.
Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.
A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice.
miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?
The role of glycogen synthase kinase-3β (GSK-3β) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker.
The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β.
GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers.
Vitamin D receptor is a novel transcriptional regulator for Axin1.
Upregulation of miR-501-5p activates the wnt/β-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer.
Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway.
Roles of tau protein in health and disease.
Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.
Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.
Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.
SPSB3 targets SNAIL for degradation in GSK-3β phosphorylation-dependent manner and regulates metastasis.
Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease.
LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.
GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals.
Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis.
TTC36 promotes proliferation and drug resistance in hepatocellular carcinoma cells by inhibiting c-Myc degradation.
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.
Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles.
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.
Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.
Human dynamin-like protein interacts with the glycogen synthase kinase 3beta.
DVL recruits GSK3beta:AXIN1 to the receptor complex
Assembly of the destruction complex
Phosphorylation of APC component of the destruction complex
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
Association of beta-catenin with the destruction complex
Phosphorylation of beta-catenin at Ser45 by CK1 alpha
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta
Beta-catenin is released from the destruction complex
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
Degradation of ubiquitinated beta catenin by the proteasome
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
AKT1 E17K mutant phosphorylates GSK3
Constitutive phosphorylation by GSK3
Regulation of HSF1-mediated heat shock response
Phosphorylation of CRMPs by GSK3beta
Disassembly of the destruction complex and recruitment of AXIN to the membrane
APC truncation mutants have impaired AXIN binding
CTNNB1 S45 mutants aren't phosphorylated by CK1alpha
CTNNB1 S33 mutants aren't phosphorylated by GSK3beta
CTNNB1 S37 mutants aren't phosphorylated by GSK3beta
CTNNB1 T41 mutants aren't phosphorylated by GSK3beta
AXIN mutants destabilize the destruction complex
Truncated AMER1 mutants destabilize the destruction complex
AXIN is phosphorylated in the destruction complex
FRAT proteins bind GSK3beta
Misspliced GSK3beta mutants stabilize beta-catenin levels
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6
GSK3 phosphorylates p-GLI3
Maturation of nucleoprotein
GSK3 phosphorylates Nucleoprotein
Maturation of nucleoprotein
GSK3 phosphorylates nucleoprotein
GSK3B phosphorylates p-NFE2L2
GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405
GSK3B phosphorylates p-S73 MITF-M at residue S69
GSK3B phosphorylates CD274
GSK3B phosphorylates CDC25A
frog CK1gamma phosphorylates LRP5/6
Murine Axin1 is further phosphorylated by Human GSK3beta
GSK3B phosphorylates Runx2
UniProt text export for GSK3B (P49841)
Manual GSK3B review notes