Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.
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Identified DVE-1 as essential for UPR-mt signaling via genome-wide RNAi screen.
"Unfolded protein stress in the mitochondria correlates with complex formation between a homeodomain-containing transcription factor DVE-1 and the small ubiquitin-like protein UBL-5, both of which are encoded by genes required for signaling the UPR(mt)"
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DVE-1 forms stress-dependent complex with UBL-5.
"Unfolded protein stress in the mitochondria correlates with complex formation between a homeodomain-containing transcription factor DVE-1 and the small ubiquitin-like protein UBL-5"
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DVE-1 redistributes to nucleus and binds promoters of mitochondrial chaperone genes under stress.
"Activation of the UPR(mt) correlates temporally and spatially with nuclear redistribution of DVE-1 and with its enhanced binding to the promoters of mitochondrial chaperone genes"
The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling.
SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.
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ULP-4 desumoylates DVE-1 at K327 to enable nuclear accumulation during UPR-mt.
"during mitochondrial stress, ULP-4 deSUMOylates DVE-1 at K327 residue to allow its nuclear accumulation to initiate UPRmt"
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SUMOylated DVE-1 is retained in cytosol.
"Conversely, SUMO-mimetic DVE-1 constitutively localized in the cytosol (Figure 3G)"
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DVE-1 interacts with ULP-4 and SMO-1 (SUMO).
"DVE-1 interacts with ULP-4 and SMO-1 in yeast two-hybrid assay"
NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level.
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DVE-1 associates with NuRD complex via LIN-40.
"NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level"
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Acetyl-CoA levels regulate chromatin remodeling and NuRD/DVE-1 nuclear accumulation.
"NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level"
Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.
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HDA-1 interacts and coordinates with DVE-1 genome organizer.
"HDA-1 interacts and coordinates with the genome organizer DVE-1 to induce the transcription of a broad spectrum of UPRmt, innate immune response and metabolic reprogramming genes"
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Together they induce transcription of UPR-mt, innate immune, and metabolic genes.
"HDA-1 interacts and coordinates with the genome organizer DVE-1 to induce the transcription of a broad spectrum of UPRmt, innate immune response and metabolic reprogramming genes"
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dve-1 RNAi suppresses immune response and survival against pathogens.
"hda-1 or dve-1 RNAi also suppressed the activation of the immune response and reduced the survival rate when the animals were challenged with another mitochondrial insult, a Rhodococcus strain isolated from the natural habitat of C. elegans"
NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans.
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DVE-1 binds to nhr-80 promoter and transactivates its expression.
"The transcription factor DVE-1 binds to the promoter of the nuclear hormone receptor nhr-80 to transactivate its expression"
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DVE-1-NHR-80 axis links UPR-mt to lipid metabolism.
"our work uncovers a DVE-1-NHR-80-lipogenesis axis linking the transmission of the mitochondrial stress signal to lipid metabolism"
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Inactivation of DVE-1 abolishes citrate-induced lipid accumulation.
"Inactivation of DVE-1 or NHR-80 fully abolishes the citrate-induced lipid accumulation"
Deep research on DVE-1 function
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DVE-1 regulates thousands of genes including those involved in lipid metabolism, innate immunity, and longevity.
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DVE-1 functions as a chromatin organizer similar to mammalian SATB family proteins.
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DVE-1 is required for embryonic development.