Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
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Human AADAT catalyzes the conversion of alpha-aminoadipate to alpha-ketoadipate, an intermediate step in lysine degradation; bacterial expression of the gene confirmed AADAT enzyme activity.
"Bacterial expression studies confirm that the gene encodes for AADAT activity."
Crystal structure of human kynurenine aminotransferase II.
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Human kynurenine aminotransferase II (KAT II) efficiently transaminates kynurenine to kynurenic acid and is a fold-type I PLP-dependent enzyme.
"Human kynurenine aminotransferase II (hKAT-II) efficiently catalyzes the"
Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II.
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Systematic substrate and kinetic characterization shows AADAT/KAT II is a broad specificity aminotransferase; aminoadipate is the best amino-acid substrate and kynurenine transamination is a major function.
"hKAT II should be equally efficient in catalysing the transamination of"
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
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AADAT is detected in a quantitative high-confidence human mitochondrial proteome, supporting mitochondrial localization.
"Quantitative high-confidence human mitochondrial proteome"
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate
AADAT transaminates 3HKYN to xanthurenate