Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:11379879

Segregation of a mutation in CNGB1 encoding the beta-subunit of the rod cGMP-gated channel in a family with autosomal recessive retinitis pigmentosa.

Human CNGB1 G993V cosegregates with recessive retinitis pigmentosa in the studied family.

PMID:15557452

A homozygosity-based search for mutations in patients with autosomal recessive retinitis pigmentosa, using microsatellite markers.

A patient with a homozygous CNGB1 splice-donor variant has retinal degeneration and nonrecordable electroretinograms.

PMID:19299621

Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia.

Human CNGB1 C-terminal sequences bind ankyrin-G and support targeting of assembled rod channels.

PMID:20890309

Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel.

GRB14 associates with rod-channel beta-containing preparations; exact human beta construct and interface scope remain limited.

PMID:24164424

Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.

Mixed human-beta/bovine-alpha channels conduct cGMP-dependent cation currents and show altered gating after matrix metalloproteinase treatment.

PMID:34699778

Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.

Human rod CNGA1/CNGB1 forms a 3:1 cGMP-gated cation channel; beta contributes ligand recognition, the pore and asymmetric gating.

PMID:7479749

Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa.

Human CNGA1 mutations impair channel function and targeting; this is not a direct CNGB1 perturbation experiment.

PMID:7682292

A new subunit of the cyclic nucleotide-gated cation channel in retinal rods.

Cloned human beta does not produce functional channels alone but confers native-like behavior when coexpressed with human alpha.

Reactome:R-HSA-2514865

cGMP dissociates from CNG channels

The curated event explicitly includes human CNGB1 as a channel component or ciliary cargo in the recorded compartment.

Reactome:R-HSA-2514867

cGMP:CNG transports Na+ and Ca2+ into the rod outer segment

The curated event explicitly includes human CNGB1 as a channel component or ciliary cargo in the recorded compartment.

Reactome:R-HSA-3229181

CALM1:Ca2+ binds CNG channel

The curated event explicitly includes human CNGB1 as a channel component or ciliary cargo in the recorded compartment.

Reactome:R-HSA-5623524

The exocyst complex binds to RAB3IP in the ciliary targeting complex

The curated event explicitly includes human CNGB1 as a channel component or ciliary cargo in the recorded compartment.

Reactome:R-HSA-5623525

Cargo-carrying vesicles bud from the TGN

The curated event explicitly includes human CNGB1 as a channel component or ciliary cargo in the recorded compartment.

Reactome:R-HSA-5623527

VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane

The curated event explicitly includes human CNGB1 as a channel component or ciliary cargo in the recorded compartment.

Reactome:R-HSA-74031

cGMP binds CNG channel to form cGMP:CNG channel

The curated event explicitly includes human CNGB1 as a channel component or ciliary cargo in the recorded compartment.

PMID:16407240

The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties.

Native bovine GARP2 binds PDE6 and suppresses nonactivated basal activity, without significant suppression of the tested activated enzyme.

PMID:7590744

cDNA, gene structure, and chromosomal localization of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channel.

The historical human GARP clone corresponds to the current GARP2 architecture with the documented R100H sequence difference.

PMID:15634774

Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1.

Mouse Cngb1 channel disruption reduces rod current and channel abundance before progressive retinal degeneration, while soluble GARP expression remains.

PMID:10352032

Divalent cation selectivity is a function of gating in native and recombinant cyclic nucleotide-gated ion channels from retinal photoreceptors.

Recombinant bovine alpha/beta rod channels conduct sodium and calcium, with ligand- and assembly-dependent relative permeability.

PMID:16980309

Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping.

Mouse Cngb1 is required for normal ciliary channel abundance, cAMP sensitivity and kinetics of olfactory electrical signaling.

PMID:10377344

The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits.

Rat olfactory B1b assembles with the olfactory alpha subunits and contributes native-like cAMP sensitivity, sodium/potassium conduction and gating.

PMID:28053034

Simultaneous Loss of NCKX4 and CNG Channel Desensitization Impairs Olfactory Sensitivity.

CNGB1 CaM-site/NCKX4 perturbation alters adult olfactory responses and OMP amount, without a reduced OMP-positive neuron fraction or changed GAP43 signal.

PMID:21809342

Functional cGMP-gated channels in cerebellar granule cells.

Rat cultured granule cells show beta-containing CNG-channel signals at presynaptic sites and channel-associated calcium responses.

PMID:41131016

Structural mechanisms of assembly, gating, and calmodulin modulation of human olfactory CNG channel.

The engineered human olfactory 2:1:1 channel binds calmodulin at beta-subunit N- and C-terminal regions; cross-linking and deletion tests support calcium-dependent inhibition, alongside direct cAMP-dependent channel activation.

file:human/CNGB1/CNGB1-source-evidence.json

CNGB1 source and assay provenance

PMID:22786723

Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels.

Rat olfactory subunit combinations expressed in oocytes support heteromeric channel assembly and ligand-dependent functional coupling; CNGB1b changes cAMP sensitivity and membrane incorporation depends on partner subunits.