Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.
Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.
The human CST complex is a terminator of telomerase activity.
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
The structure of human CST reveals a decameric assembly bound to telomeric DNA.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
RFC binding displaces Pol Alpha on the C-strand of the telomere
DNA polymerase:primase binds G-strand of the telomere
Human CST promotes telomere duplex replication and general replication restart after fork stalling.
Human CST abundance determines recovery from diverse forms of DNA damage and replication stress.
Cryo-EM structure of the human CST-Polα/primase complex in a recruitment state.
Structures of the human CST-Polα-primase complex bound to telomere templates.
Reconstitution of a telomeric replicon organized by CST.
POT1 recruits and regulates CST-Polα/primase at human telomeres.
CST does not evict elongating telomerase but prevents initiation by ssDNA binding.
A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells.
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion.