Automatic Gene Ontology annotation of non-coding RNA sequences through association of Rfam records with GO terms
miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
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An expression survey of undifferentiated versus differentiating mouse embryonic stem cells. Differentiation was induced by LIF withdrawal, and 138 miRNAs rose during it; only miR-34a, miR-100 and miR-137 were functionally tested. mir-384 is not among the tested miRNAs and is not discussed in the paper.
"We report that 138 miRNAs are increased on the induction of differentiation"
miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.
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miR-384-5p is one of two miRNAs the study functionally establishes as required for LTP maintenance and spine enlargement, acting via RSK3.
"we demonstrate that miR-26a and miR-384-5p specifically affect the maintenance, but not induction, of LTP and different stages of spine enlargement by regulating the expression of RSK3"
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The same study profiled 372 miRNAs and found only 12 changed during LTP, describing the remainder as a candidate list.
"presents a catalogue of candidate 'LTP miRNAs'"