Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Neuroligins and neurexins link synaptic function to cognitive disease.
Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia.
ABP1 binds SHANK proteins
NRXNs bind CASK:Protein 4.1
IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.
Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus.
Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors.
Deletion of α-neurexin II results in autism-related behaviors in mice.
Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.
Conditional deletion of Neurexin-2 alters neuronal network activity in hippocampal circuitries and leads to spontaneous seizures.
Conditional deletion of neurexin-2 impaired behavioral flexibility to alterations in action-outcome contingency.
Advances in neurexin studies and the emerging role of neurexin-2 in autism spectrum disorder.
Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.
Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.
High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex.
LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation.
A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins.
Neurexins physically and functionally interact with GABA(A) receptors.
A stoichiometric complex of neurexins and dystroglycan in brain.
UniProtKB Q9P2S2 (NRXN2_HUMAN) entry
Falcon deep research report on NRXN2