Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

UniProtKB entry P07686 (HEXB_HUMAN), Beta-hexosaminidase subunit beta

Characterization of the Glu and Asp residues in the active site of human beta-hexosaminidase B.

Physiological substrates for human lysosomal beta -hexosaminidase S.

Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.

Defining the membrane proteome of NK cells.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.

Architecture of the human interactome defines protein communities and disease networks.

A reference map of the human binary protein interactome.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Association of alpha- and beta-subunits during the biosynthesis of beta-hexosaminidase in cultured human fibroblasts.

Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A.

Classification of disorders of GM2 ganglioside hydrolysis using 3H-GM2 as substrate.

Identification of domains in human beta-hexosaminidase that determine substrate specificity.

Direct determination of the substrate specificity of the alpha-active site in heterodimeric beta-hexosaminidase A.

A Pro504 --> Ser substitution in the beta-subunit of beta-hexosaminidase A inhibits alpha-subunit hydrolysis of GM2 ganglioside, resulting in chronic Sandhoff disease.

bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3

bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE

HEXA cleaves the terminal GlcNAc from keratan sulfate

HEXA cleaves the terminal GalNAc from DS

HEXA cleaves the terminal GlcNAc from small HA fragments

Exocytosis of azurophil granule lumen proteins

Defective HEXB does not cleave the terminal GalNAc from HA fragments

HEXB cleaves the terminal GalNAc from DS

HEXB cleaves the terminal GlcNAc from small HA fragments

HEXB cleaves the terminal GlcNAc from keratan sulfate

bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer

bHEXA,bHEXS hydrolyze GM2A:SM2