Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm.
The sonic hedgehog-patched-gli pathway in human development and disease.
Patched1 interacts with cyclin B1 to regulate cell cycle progression.
Comparative biological responses to human Sonic, Indian, and Desert hedgehog.
Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation.
Reduced thymocyte development in sonic hedgehog knockout embryos.
Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation.
Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo.
Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development.
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog.
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
A new role for Hedgehogs in juxtacrine signaling.
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Structural basis for the recognition of Sonic Hedgehog by human Patched1.
Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.
A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities.
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly.
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.
P4HB forms mixed disulphides with Hh precursors
Autoproteolytic cleavage of Hh precursors
HHAT palmitoylates Hh N-terminal fragment
HPE SHH variants don't undergo autoproteolytic cleavage
SYVN1 ubiquitinates Hh C-terminal fragments
C-terminal Hh fragments are bound by lectins
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
Hh C-terminal fragments are degraded by the proteasome
Hh processing variants bind lectins
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
Hh-Np traffics to the plasma membrane
Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling
NOTUM releases Hh-Np:GPC5 from the plasma membrane
Hh processing variants are recruited to SEL1:SYVN at the ER membrane
Hh processing variants are translocated to the cytosol in a VCP-dependent manner
processing defective Hh variants are degraded by the proteasome
HHAT G287V doesn't palmitoylate Hh-Np
Hh processing variants are ubiquitinated
Hh-Npp binds GAS1 and PTCH
Hh-Npp binds CDON and PTCH
mouse Disp2 binds SHH N-terminal fragment
Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum.