LYS21 (YDL131W, Q12122) notes

Pathway context: LYSINE-AMINOAD-PWY-2 step 1 (EC 2.3.3.14), paralog of LYS20.

• Activity / regulation: PMID:10103047; PMID:18524920; main isozyme on ethanol PMID:18524920.
• Location: nucleus PMID:9099739. UniProt names it "mitochondrial" with SubCell Mitochondrion {ECO:0000305} [UniProt:Q12122]; no direct evidence and not in mito proteome GOA rows (unlike LYS20) -> IEA mitochondrion marked over-annotated.
• Decisions: protein binding REMOVE; generic IEA MODIFY -> GO:0004410; zinc binding non-core; cytosol RCA non-core.