Falcon deep research report for PFDN5
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.
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Discovered the heterohexameric chaperone protein prefoldin, based on its ability to capture unfolded actin. Prefoldin binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. Deletion of the gene encoding a prefoldin subunit in S. cerevisiae results in impaired actin and tubulin-based cytoskeleton functions.
"We describe the discovery of a heterohexameric chaperone protein, prefoldin, based on its ability to capture unfolded actin. Prefoldin binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it."
MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Stimulation of c-Myc transcriptional activity by vIRF-3 of Kaposi sarcoma-associated herpesvirus.
Negative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 gene.
Next-generation sequencing to generate interactome datasets.
Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis.
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Used cryo-EM, crosslinking mass spectrometry, and biochemical approaches to characterize the PFD-TRiC supra-chaperone assembly. Demonstrated that PFD enhances the rate and yield of TRiC-mediated protein folding, and that disrupting the TRiC-PFD interaction leads to accumulation of amyloid aggregates.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
The functions and mechanisms of prefoldin complex and prefoldin-subunits.
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Comprehensive review of prefoldin complex functions and individual subunit roles. Describes PFDN5/MM-1 as the most well-known prefoldin subunit with documented c-Myc corepressor function through multiple mechanisms: HDAC-mSin3 recruitment, Rabring7-mediated c-Myc degradation, and Wnt4 repression via Egr-1.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A comprehensive analysis of prefoldins and their implication in cancer.
Multimodal cell maps as a foundation for structural and functional genomics.