Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function.
Functional characterization of calcium-sensing receptor codon 227 mutations presenting as either familial (benign) hypocalciuric hypercalcemia or neonatal hyperparathyroidism.
Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly.
Protein kinase C-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase activity.
Neonatal severe hyperparathyroidism associated with a novel de novo heterozygous R551K inactivating mutation and a heterozygous A986S polymorphism of the calcium-sensing receptor gene.
A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia.
The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway.
Calcium sensing receptor mutations implicated in pancreatitis and idiopathic epilepsy syndrome disrupt an arginine-rich retention motif.
A novel mutation in the calcium-sensing receptor in a French family with familial hypocalciuric hypercalcaemia.
Agonist-driven maturation and plasma membrane insertion of calcium-sensing receptors dynamically control signal amplitude.
CASR gene activating mutations in two families with autosomal dominant hypocalcemia.
Two novel mutations of the calcium-sensing receptor gene affecting the same amino acid position lead to opposite phenotypes and reveal the importance of p.N802 on receptor activity.
Loss-of-function and gain-of-function mutations of calcium-sensing receptor: functional analysis and the effect of allosteric modulators NPS R-568 and NPS 2143.
Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population.
A novel mutation in calcium-sensing receptor gene associated to hypercalcemia and hypercalciuria.
Novel activating mutation of human calcium-sensing receptor in a family with autosomal dominant hypocalcaemia.
Identification and functional analysis of a novel CaSR mutation in a family with familial hypocalciuric hypercalcemia.
Structural mechanism of ligand activation in human calcium-sensing receptor.
Illuminating the allosteric modulation of the calcium-sensing receptor.
Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis.
Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca(2+) ions and L-tryptophan.
Asymmetric activation of the calcium-sensing receptor homodimer.
Structural insights into the activation of human calcium-sensing receptor.
Allosteric modulation and G-protein selectivity of the Ca(2+)-sensing receptor.
Promiscuous G-protein activation by the calcium-sensing receptor.
Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs.
Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation.
Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.
Clustered inactivating mutations and benign polymorphisms of the calcium receptor gene in familial benign hypocalciuric hypercalcemia suggest receptor functional domains.
Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor.
Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells.
Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release.
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
Liganded Gi-activating GPCR acts as a GEF for Gi
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
The Ligand:GPCR:Gq complex dissociates
The Ligand:GPCR:Gi complex dissociates
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor.