Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Global analysis of protein localization in budding yeast.
Rational extension of the ribosome biogenesis pathway using network-guided genetics.
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TSR4 was identified as a ribosome biogenesis factor
"We experimentally evaluated >100 candidate yeast genes in a battery of assays, confirming involvement of at least 15 new genes, including previously uncharacterized genes (YDL063C, YIL091C, YOR287C, YOR006C/TSR3, YOL022C/TSR4)."
Tsr4 and Nap1, two novel members of the ribosomal protein chaperOME.
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Tsr4 is a direct, cotranslational Rps2/uS5 chaperone that promotes client solubility.
"We report the identification of Nap1 and Tsr4 as direct binding partners of Rps6 and Rps2, respectively. Both factors promote the solubility of their r-protein clients in vitro."
Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rps2 in Saccharomyces cerevisiae.
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Tsr4 is a cytoplasmic chaperone dedicated to Rps2
"Here, we report that Tsr4 cotranslationally associates with Rps2. Rps2 harbors a eukaryote-specific N-terminal extension that is critical for its interaction with Tsr4."
Falcon deep research report for TSR4
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TSR4 is a cytoplasmic, client-specific uS5/Rps2 chaperone.
"**Molecular function (best-supported):** Tsr4 binds **nascent Rps2/uS5** co-translationally in the cytoplasm and acts as a **client-specific chaperone** to stabilize Rps2 and support 40S biogenesis (black2019tsr4isa pages 1-3, rossler2019tsr4andnap1 pages 12-13)."