loqs review notes

The selected accession is the native 464 aa PF isoform (FlyBase FBpp0309562), not PD. Sequence analysis verifies one lysine difference relative to 465 aa PB and retention of all three DRBM domains. No wrong-input claim is warranted.

PMID:17666393(https://pubmed.ncbi.nlm.nih.gov/17666393/) explicitly assigns pre-miRNA binding to DRBM2 and Dcr-1 binding to DRBM3. This justifies PB-to-PF transfer for the broad core activity. PMID:19635780(https://pubmed.ncbi.nlm.nih.gov/19635780/) resolves the distinct PD siRNA role, so gene-level siRNA annotations remain UNDECIDED for exact PF rather than being removed. Germline/CNS phenotypes are retained as non-core, with experimental isoform limits explicit.

The broad prediction is LSP; the accompanying mammalian complex narrative needs pathway-specific correction. Raw predictions and source metadata are preserved. Missing fulltext flags are set from publication caches; the abstract-only papers explicitly support the quoted gene-level claims without inventing unobserved assay details.

Falcon completed and was read. It distinguishes PB and PD and identified PMID:17928574(https://pubmed.ncbi.nlm.nih.gov/17928574/) on Loqs dispensability for miRISC assembly; this publication was fetched and inspected directly. Its unresolved PF identity is addressed by the local sequence comparison. The narrative separates complex association from an obligatory RISC-assembly role. The advisory about no direct Falcon citation is accepted because consequential claims cite the underlying sources.