Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
HEF1-dependent Aurora A activation induces disassembly of the primary cilium.
The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.
The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes.
Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex.
A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.
The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis.
RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly.
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects.
A reference map of the human binary protein interactome.
CCDC66 regulates primary cilium length and signaling via interactions with transition zone and axonemal proteins.
Assembly of the anterograde IFT train
Assembly of the retrograde IFT train
The anterograde IFT train dissociates
The retrograde IFT train dissociates
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1
Parkin transfers Ub to misfolded proteins
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor
PolyUb-Misfolded proteins bind vimentin to form aggresome
Aggresome dissociates from dynein and microtubule
Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella.
Hedgehog signalling in the mouse requires intraflagellar transport proteins.