Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1.
TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly.
The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.
A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation.
GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.
Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment.
FBXL5 interacts with p150Glued and regulates its ubiquitination.
CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1.
Structure-function relationship of CAP-Gly domains.
Interaction of tau protein with the dynactin complex.
Novel interaction partners of Bardet-Biedl syndrome proteins.
Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued.
Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking.
Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin.
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons.
Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly.
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning.
The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.
The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.
Defining the membrane proteome of NK cells.
Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.
Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase.
Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment.
A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
PEX14 is required for microtubule-based peroxisome motility in human cells.
Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein.
Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments.
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation.
Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued).
The centriolar satellite protein Cep131 is important for genome stability.
Cortical dynein is critical for proper spindle positioning in human cells.
3D-structured illumination microscopy provides novel insight into architecture of human centrosomes.
Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
PtdIns(4)P regulates retromer-motor interaction to facilitate dynein-cargo dissociation at the trans-Golgi network.
The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.
Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor.
Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome.
Cep126 is required for pericentriolar satellite localisation to the centrosome and for primary cilium formation.
Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein.
HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes.
Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome.
The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Roles of tau protein in health and disease.
Regulation of spindle integrity and mitotic fidelity by BCCIP.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin.
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells.
Transport of antigen loaded MHC II molecules to surface
AJUBA facilitates AURKA autophosphorylation
AJUBA binds centrosome-associated AURKA
AURKA phosphorylates PLK1
BORA binds PLK1 and AURKA
Plk1-mediated phosphorylation of Nlp
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Dissociation of Phospho-Nlp from the centrosome
Recruitment of Plk1 to centrosomes
Association of NuMA with microtubules
Recruitment of CDK11p58 to the centrosomes
Translocation of NuMA to the centrosomes
RAB3IP stimulates nucleotide exchange on RAB8A
C2CD3 binds the mother centriole
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
CP110 and CEP97 dissociate from the centriole
The distal appendage proteins recruit TTBK2
Recruitment of transition zone proteins
MARK4 binds ODF2 in the centriole
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
ERGIC-to-Golgi vesicles bind dynein:dynactin
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex
RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex
Dynein drives COPI-independent retrograde traffic from the Golgi to the ER
TPX2 binds AURKA at centrosomes
TPX2 promotes AURKA autophosphorylation
Ligand-independent dimerization of ALK fusions
Autophosphorylation of ALK fusions
PI3K synthesizes PIP3 downstream of ALK mutants
UniProtKB entry Q14203 (DCTN1_HUMAN)
Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes.
The structure of the dynactin complex and its interaction with dynein.
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration.
Nesprin-2 coordinates opposing microtubule motors during nuclear migration in neurons.
Molecular mechanism of dynein-dynactin complex assembly by LIS1.
Falcon deep research report for DCTN1