Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Twitching motility contributes to the role of pili in corneal infection caused by Pseudomonas aeruginosa.
-
A pilA mutant of strain PAK lacks pili and twitching, and is reduced in association with and invasion of corneal epithelial cells.
"The pilA mutant is twitching motility negative because it lacks pili"
Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms.
Surface plasmon resonance shows that type IV pili are important in surface attachment by Pseudomonas aeruginosa.
Type IV pilus protein PilA of Pseudomonas aeruginosa modulates calcium signaling through binding the calcium-modulating cyclophilin ligand.
A phage protein that inhibits the bacterial ATPase required for type IV pilus assembly.
Type IV pilins regulate their own expression via direct intramembrane interactions with the sensor kinase PilS.
-
Unassembled PilA interacts with PilS in the inner membrane to autoregulate pilA transcription.
"direct interactions between PilA and PilS in the inner membrane reduce pilA transcription when PilA levels are high"
Cloning and sequencing of the Pseudomonas aeruginosa PAK pilin gene.
Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus.
-
Cryo-EM structure of the native PAO1 type IV pilus, a helical polymer of PilA.
"PilA subunits constituting the T4P exhibit a classical pilin fold"
Genes involved in the biogenesis and function of type-4 fimbriae in Pseudomonas aeruginosa.
UniProt entry P04739 (PILA_PSEAE)