The actual PANTHER tree was retrieved on 2026-09-20 by POST to the treeinfo endpoint with family=PTHR16201. The accession-mapped target Q03193 has the following lineage:
PTN001044753 → PTN004490975 → PTN008358244 → PTN000415973 → PTN008563932 → PTN001044796 → PTN000415974 → PTN000415975 → PTN001044797 → PTN001044798 → PTN000415976.
All four disputed inherited annotations originate at PTN001044753 and remain positive on target leaf PTN000415976. The target lies in subfamily SF37 below that ancestor, so characterized descendants in other subfamilies are not evidence of a misplaced pairwise transfer. No loss assertion was found on the inspected target lineage.
Primary PMID30045857 establishes plasma-membrane localization of functionally tested chromosomal GFP fusions and background-dependent cationic-xenobiotic tolerance. It does not test vacuolar localization under all conditions or basic-amino-acid transport, and thus does not contradict the inherited vacuolar transport and homeostasis functions. The mechanistic contribution to xenobiotic tolerance remains unestablished.
Exact lineage, response hash and bytes, target GAF rows, lineage-node assertions, separately marked off-lineage assertions, and current term definitions are preserved in ILT1-paint-lineage.json. The source tree is https://www.pantherdb.org/services/oai/pantherdb/treeinfo; GO definitions were retrieved from the QuickGO ontology API.