Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Global analysis of protein localization in budding yeast.
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.
Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribosome Is Regulated by Its Eukaryote-Specific Extension.
The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site.
Molecular basis for protection of ribosomal protein L4 from cellular degradation.
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Acl4 forms a soluble TPR complex around the Rpl4 loop and protects Rpl4 from degradation during its handoff to nuclear import.
"Thus, Acl4 serves a dual function to facilitate nuclear import and simultaneously protect unassembled RpL4 from the cellular degradation machinery."
Dedicated chaperones coordinate co-translational regulation of ribosomal protein production with ribosome assembly to preserve proteostasis.
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Acl4 participates in a cytoplasmic Rpl4 production-control pathway that couples nascent Rpl4 recognition to RPL4 mRNA stability.
"the co-translational recognition of Rpl3 and Rpl4 by their respective dedicated chaperone, Rrb1 or Acl4, reduces the degradation of the encoding RPL3 and RPL4 mRNAs"
Functional similarities and differences among subunits of the nascent polypeptide-associated complex (NAC) of Saccharomyces cerevisiae.
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The 2024 NAC/Caf130 study genetically embeds Acl4 in Rpl4 messenger RNA production control through the Caf130 subunit of CCR4-Not.
"NacĪ²2 has been implicated in regulating the fate of messenger RNA encoding ribosomal protein Rpl4 during translation via its interaction with the Caf130 subunit of the regulatory CCR4-Not complex."
GOA annotation export for ACL4
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GOA records the phylogenetic IBA source for the ACL4 GO:0008320 annotation.
"UniProtKB Q03771 ACL4 contributes_to GO:0008320 protein transmembrane transporter activity molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN002340064|SGD:S000005065 559292 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GO_Central Assembly chaperone of RPL4 20220331"
Falcon deep research report for ACL4
OpenScientist hypothesis report for ACL4 GO:0008320
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The report computes no hydrophobic transmembrane candidate segment, which addresses integral membrane insertion rather than soluble contribution.
"**zero** transmembrane-candidate segments"
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The report recognizes Acl4 cargo escort to nuclear pre-60S assembly.
"dedicated escort chaperone"
OpenScientist hypothesis report for ACL4 mitochondrial targeting and translocation contribution
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A second focused report preserved the contributes_to qualifier and traced the mitochondrial IBA rows to TOM70-family receptor seeds rather than to Acl4-specific mitochondrial evidence.
"experimental seeds are the TPR-domain mitochondrial import receptors TOM70, TOM71, and human TOMM70"
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The same report recovered only Acl4 chaperone/ribosome-biogenesis direct evidence.
"Every direct-evidence annotation on Acl4 describes a soluble TPR assembly chaperone dedicated to ribosomal protein Rpl4/uL4."