TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
UniProtKB record A0A0H2MBK5 (A0A0H2MBK5_VARPD) - Exopolyphosphatase from Variovorax paradoxus TBEA6
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VPARA_10490 (ppx, A0A0H2MBK5) is a 506-aa exopolyphosphatase (EC 3.6.1.11) containing an N-terminal Ppx/GppA phosphatase domain (Pfam PF02541, residues 23-307) and a C-terminal Ppx/GppA domain (Pfam PF21447, residues 315-480), classified under PANTHER PTHR30005:SF14 (EXOPOLYPHOSPHATASE).
"FT DOMAIN 23..307
FT /note="Ppx/GppA phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02541""
Accumulation of inorganic polyphosphate enables stress endurance and catalytic vigour in Pseudomonas putida KT2440.
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Bacterial exopolyphosphatase (Ppx) catalyzes the hydrolysis of inorganic polyphosphate chains to orthophosphate (Pi), operating alongside polyphosphate kinase (Ppk) in the intracellular polyphosphate cycle.
"In addition to Ppk, there is another polyP-modifying enzyme: the so-called exopolyphosphatase (Ppx), that is in charge of polyP hydrolysis to Pi (Figure 1A)."