GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms.

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods.

PMID:32296183

A reference map of the human binary protein interactome.

HuRI systematic proteome-wide yeast two-hybrid screen identified binary protein interactions for STOML3 with ADAM33, CLDN19, JAGN1, SEC22A, UPK2, and ZDHHC24.

"The dataset, versioned HI-III-20 (Human Interactome obtained from screening Space III, published in 2020), contains 52,569 verified PPIs involving 8,275 proteins (Supplementary Table 9)."

Reactome:R-HSA-8863494

ASICs bind STOML3, (STOM)

STOML3 and stomatin are accessory proteins for ASIC channels, modulating their gating properties. STOML3 binds ASIC1a, 1b, 2a, 2b, 3 and 4.

"STOML3 can bind ASIC1a, 1b, 2a, 2b, 3 and 4 (Lapatsina et al. 2012)"

DOI:10.1038/ncomms4520

Tuning piezo ion channels to detect molecular-scale movements relevant for fine touch

STOML3 lowers the activation threshold of Piezo1 and Piezo2 to approximately 10 nm displacements. Stoml3 knockout neurons require approximately 10-fold larger displacements for activation. The stomatin domain and higher-order oligomerization are required for this sensitizing activity.

DOI:10.1038/ncomms9512

Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons

STOML3 binds cholesterol and stiffens local membrane domains to facilitate force transfer and sensitize mechanogated channels. Cholesterol depletion phenocopies STOML3 loss. AFM and mechanical assays demonstrate that both cholesterol depletion and STOML3 deficiency similarly reduce membrane stiffness and mechanosensitivity.

DOI:10.1098/rsob.120096

Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons

STOML3 directly interacts with ASIC subunits (ASIC1a, 1b, 2a, 2b, 3, 4) demonstrated by co-immunoprecipitation and FRET. STOML3-positive vesicles are Rab11-positive and microtubule-dependent. The N-terminal hydrophobic region is required for vesicular localization.

DOI:10.17863/cam.7374

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

High-throughput BiFC screening identified small molecules (OB-1, OB-2) that inhibit STOML3 oligomerization, shrink STOML3 nanoclusters, reduce mechanically-activated currents, silence mechanoreceptors, and reverse mechanical hypersensitivity in neuropathic and diabetic models.

file:human/STOML3/STOML3-deep-research-openai.md

Deep research on STOML3 function

file:human/STOML3/STOML3-deep-research-cyberian.md

Cyberian deep research on STOML3 function