Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.
Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.
Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2.
Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis.
Deletion of 3 residues from the C-terminus of MCFD2 affects binding to ERGIC-53 and causes combined factor V and factor VIII deficiency.
The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Role of syntaxin 18 in the organization of endoplasmic reticulum subdomains.
A novel missense mutation causing abnormal LMAN1 in a Japanese patient with combined deficiency of factor V and factor VIII.
Defining the membrane proteome of NK cells.
Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII.
Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency.
C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.
Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Structural basis for disparate sugar-binding specificities in the homologous cargo receptors ERGIC-53 and VIP36.
TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
The E3 ubiquitin ligase MARCH2 regulates ERGIC3-dependent trafficking of secretory proteins.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of FV and FVIII.
Cargo selection in endoplasmic reticulum-to-Golgi transport and relevant diseases.
Structure of full-length ERGIC-53 in complex with MCFD2 for cargo transport.
LMAN1 serves as a cargo receptor for thrombopoietin.
ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells.
Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII.
Molecular cloning of the oncofetal isoform of the human pancreatic bile salt-dependent lipase.
SEC31:SEC13 and v-SNARE recruitment
Nucleotide exchange on RAB1
SEC16 complex binds SAR1B:GTP:SEC23:SEC24
RAB1:GTP binds USO1 and GORASP1:GOLGA2
LMAN family proteins bind glycosylated cargo
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors
COPII coat binds TRAPPCII and RAB1:GDP
CSNK1D phosphorylates SEC23
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle
Inner coat assembly and cargo binding
Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi
UniProt entry P49257 (LMAN1_HUMAN), Protein ERGIC-53