FAMA (At3g24140, Q56YJ8) curation notes

Session 2026-10-06 (stomatal_lineage_development module). Falcon deep research failed (HTTP 402).

Key findings

• Required for guard cell differentiation and to halt GMC proliferative divisions; nuclear; transcriptional activator PMID:17088607.
• SPCH, MUTE, FAMA act at three consecutive steps PMID:17183267; each acts as heterodimer with SCRM/ICE1 PMID:18641265.
• FAMA-RBR (LxCxE) module enforces irreversible GC fate PMID:25303364; redundancy with FLP/MYB88 PMID:24571519; epigenetic stabilization of GC identity PMID:24654956.
• FAMA locus methylated/repressed under low humidity PMID:22442411 (expression response only).

Curation decisions

• Core MFs: DNA-binding transcription factor activity (accepted); protein heterodimerization activity (NEW, IPI PMID:18641265); transcription coregulator binding (NEW; RBR protein binding rows MODIFIED).
• Core BPs: guard cell differentiation; guard cell fate commitment.
• Low humidity IEP kept non-core.
• No GO-CAM models contain FAMA.