Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Proteomics characterization of abundant Golgi membrane proteins.
A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic.
Rabring7, a novel Rab7 target protein with a RING finger motif.
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.
Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis.
TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.
Trafficking of cGMP-dependent protein kinase II via interaction with Rab11.
The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum.
Derlin-dependent accumulation of integral membrane proteins at cell surfaces.
An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7.
Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2.
Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes.
V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorption.
Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages.
Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin.
β-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation.
-
Rab7 is required for lipophagy of lipid droplets in fat cells
"RAB7 plays a pivotal role in the regulation of this autolysosome-mediated lipid degradation in fat cells."
-
LD-associated Rab7 mediates autophagic targeting of lipid droplets
"ADRB2 stimulation has caused a marked increase in the autophagy-targeted LDs for lysosomal degradation, which is dependent on the LD-associated RAB7"
Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development.
Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression.
The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function.
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA.
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells.
Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.
PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.
Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy.
Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment.
-
Rab7 is a small GTPase involved in organelle trafficking, recruited to secretory lysosomes in a V-ATPase a3-dependent manner
"Rab7, a small GTPase involved in organelle trafficking."
TMED2 binding restricts SMO to the ER and Golgi compartments.
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts.
-
RUFY4 is an effector of small GTPases including Rab7
"Recent studies have shown that RUFY4 is an effector of small GTPases such as Rab7"
-
Rab7 is enriched at the osteoclast ruffled border and required for bone resorption
"Notably, Rab7 is highly expressed at the ruffled border of bone-resorbing osteoclasts and its knockdown disrupts both the targeting of vesicles to the ruffled border and bone resorption."
In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery.
-
Rab7 is a mediator of late endosomal maturation; its loss increases cytosolic escape of lipid nanoparticles in mouse liver
"Loss of Rab7, a mediator of late endosomal maturation, increased LNP escape."
-
LysoTag mice enable immunoisolation of liver lysosomes to quantify in vivo endosomal escape
"we used LysoTag mice, which allow immunoisolation of liver lysosomes"
Manual research synthesis for mouse Rab7 (deep-research providers unavailable)