Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
COL5A1 exon 14 splice acceptor mutation causes a functional null allele, haploinsufficiency of alpha 1(V) and abnormal heterotypic interstitial fibrils in Ehlers-Danlos syndrome II.
Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin.
Reduced type I collagen utilization: a pathogenic mechanism in COL5A1 haplo-insufficient Ehlers-Danlos syndrome.
The COL5A1 gene and Achilles tendon pathology.
Structural abnormalities of the cornea and lid resulting from collagen V mutations.
Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1.
Proteomics characterization of extracellular space components in the human aorta.
Focus on molecules: collagens V and XI.
Identification of binding partners interacting with the α1-N-propeptide of type V collagen.
Primary structure of the heparin-binding site of type V collagen.
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Architecture of the human interactome defines protein communities and disease networks.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Collagen Fibril Assembly and Function.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The Chemistry and Biology of Collagen Hybridization.
Multimodal cell maps as a foundation for structural and functional genomics.
Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB).
Mutations in the COL5A1 gene are causal in the Ehlers-Danlos syndromes I and II.
The membrane-spanning proteoglycan NG2 binds to collagens V and VI through the central nonglobular domain of its core protein.
A point mutation in an intronic branch site results in aberrant splicing of COL5A1 and in Ehlers-Danlos syndrome type II in two British families.
Formation of collagen fibrils
Collagen type V degradation by MMP2,9,10
Removal of fibrillar collagen N-propeptides
Removal of fibrillar collagen C-propeptides
Procollagen triple helix formation
Formation of collagen fibres
Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1
FN1 binds Collagen types I-V, VII
DDR1 binds collagen type I, II, III, IV, V, XI fibrils
VTN binds collagens II, III and V
DDR2 binds collagen type I, II, III, V, X fibrils
Interaction of NCAM1 with collagens
PDGF binds to extracellular matrix proteins
Association of procollagen type V
Syndecan-1 binds collagen types I, III, V
Differences in chain usage and cross-linking specificities of cartilage type V/XI collagen isoforms with age and tissue.
Type V collagen controls the initiation of collagen fibril assembly.
A domain-specific usherin/collagen IV interaction may be required for stable integration into the basement membrane superstructure.