Mo25 (CG4083; UniProt P91891) notes

• MO25/CAB39 family armadillo-like scaffold (UniProt: "Belongs to the Mo25 family").
• Fly Mo25 binds LKB1 in vivo and acts with the GC kinase Fray in neuroblast asymmetric division
  PMID:18054329;
  PMID:18054329.
• Localization: cytoplasmic, relocalized to cortex by LKB1 overexpression
  PMID:18054329.
• LKB1 cofactor in fly S2R+ cells; co-IP with LKB1 together with Stlk
  PMID:36899949.
• LKB1 complex activity lowers mTOR PMID:36899949
  -> GOA "positive regulation of TORC1 signaling" (TAS) has the wrong sign; MODIFY to negative regulation (consistent with Lkb1 review).

Deep research

• Falcon deep research: the first run was killed (exit 137); a retry produced Mo25-deep-research-falcon.md, describing Mo25 as a kinase-regulatory scaffold for both LKB1 and the GC kinase Fray: [file:DROME/Mo25/Mo25-deep-research-falcon.md "Fly Mo25 enhances the kinase activity of Fray in vitro"].

Decisions

• ND root MF -> MODIFY to protein serine/threonine kinase activator activity (GO:0043539).
• Core: GO:0043539 in the LKB1-Stlk-Mo25 complex (GO:1902554), cytoplasm.