Automatic Gene Ontology annotation of non-coding RNA sequences through association of Rfam records with GO terms
MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein.
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miR-26a/b act with their CTDSP host genes to reduce phosphorylated pRb and block G1/S progression, via direct target suppression.
"Gain- and loss-of-function studies showed that miR-26a/b and CTDSP1/2/L synergistically decreased the phosphorylated form of pRb (ppRb), and blocked G1/S-phase progression"
Profiling circulating microRNA expression in experimental sepsis using cecal ligation and puncture.
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A circulating-miRNA biomarker survey in a cecal ligation and puncture sepsis model. miR-26a is one of 10 miRNAs upregulated in whole blood and serum, and one of 6 enriched in exosomes, with Argonaute 2 immunoprecipitation confirming RISC association.
"the levels of 6 (miR-16, miR-17, miR-20a, miR-20b, miR-26a, and miR-26b) of these 10 miRNA targets increased significantly in exosomes"
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The study's own knockout controls exclude bacterium-sensing pathways as the cause of the change, so the observation does not support a role for these miRNAs in responding to bacteria.
"which indicated that the transcription of these miRNAs was not directly mediated by the TLR2/NF-κB or TLR4/NF-κB pathway, and pathways induced by exposure to the gram-positive or gram-negative bacteria"
miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.
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miR-26a is functionally required for the maintenance phase of LTP and for spine enlargement, acting by repressing RSK3 through its 3' UTR.
"we demonstrate that miR-26a and miR-384-5p specifically affect the maintenance, but not induction, of LTP and different stages of spine enlargement by regulating the expression of RSK3"
MiR-154-5p regulates osteogenic differentiation of adipose-derived mesenchymal stem cells under tensile stress through the Wnt/PCP pathway by targeting Wnt11.
miR-181b negatively regulates activation-induced cytidine deaminase in B cells.
MicroRNA expression and regulation in mouse uterus during embryo implantation.