Annotation inferences using phylogenetic trees
Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.
GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.
Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.
A reference map of the human binary protein interactome.
4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.
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4EHP-GIGYF1/2 complexes trigger co-translational mRNA decay; cells lacking them accumulate ribosome-paused transcripts, and the complex requires its interactions with the cap, DDX6 and ZNF598 to reduce mRNA levels.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation.
Systematic identification of post-transcriptional regulatory modules.
UniProt entry O75420 (GGYF1_HUMAN)
GOA annotations for GIGYF1