Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
lon-1 regulates Caenorhabditis elegans body size downstream of the dbl-1 TGF beta signaling pathway.
Genetic screen for small body size mutants in C. elegans reveals many TGFbeta pathway components.
Mutants carrying two sma mutations are super small in the nematode C. elegans.
Pattern formation in the nematode epidermis: determination of the arrangement of peripheral sense organs in the C. elegans male tail.
A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans.
Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.
Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
The expression of TGFbeta signal transducers in the hypodermis regulates body size in C. elegans.
C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation.
Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans.
Deep research report on sma-2
TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance.
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Sma/Mab TGF-beta signalling regulates reproductive aging; sma-2 mutants keep young-looking oocytes.
"By contrast, oocytes in aged daf-2 and sma-2 animals were still young-looking, with significantly fewer morphological defects than age-matched wild type oocytes"
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The reproductive-span effect is noncell-autonomous and separable from growth control.
"TGF-β activity regulates reproductive span and germline/oocyte quality noncell-autonomously and is temporally and transcriptionally separable from its regulation of growth."
WormBase gene description for sma-2 (worm)